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Witucki, Łukasz
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dr
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2023 - 2024
5
Author
Jakubowski, Hieronim
5
Witucki, Łukasz
5
Borowczyk, Kamila
1
Pawlak, Piotr
1
Suszyńska-Zajczyk, Joanna
1
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Subject
autophagy
homocysteine thiolactone
4
H4K20me1
3
mTOR
3
Phf8
3
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5
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Journal article
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Publication
2024
Homocysteine metabolites inhibit autophagy by upregulating miR-21-5p, miR-155-5p, miR-216-5p, and miR-320c-3p in human vascular endothelial cells
Witucki, Łukasz
Jakubowski, Hieronim
29
29
Publication
2023
Homocysteine metabolites inhibit autophagy, elevate amyloid beta, and induce neuropathy by impairing Phf8/H4K20me1-dependent epigenetic regulation of mTOR in cystathionine β-synthase-deficient mice
Witucki, Łukasz
Jakubowski, Hieronim
17
17
Publication
2023
Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer’s Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer’s Disease
Witucki, Łukasz
Borowczyk, Kamila
Suszyńska-Zajczyk, Joanna
Warzych-Plejer, Ewelina
Pawlak, Piotr
Jakubowski, Hieronim
15
15
Publication
2023
Homocysteine Metabolites Impair the PHF8/H4K20me1/mTOR/Autophagy Pathway by Upregulating the Expression of Histone Demethylase PHF8-targeting microRNAs in Human Vascular Endothelial Cells and Mice
Witucki, Łukasz
Jakubowski, Hieronim
4
4
Publication
2023
Depletion of Paraoxonase 1 (Pon1) Dysregulates mTOR, Autophagy, and Accelerates Amyloid Beta Accumulation in Mice
Witucki, Łukasz
Jakubowski, Hieronim
5
5