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Evaluation of probiotics in vegetable juices: tomato (Solanum lycopersicum), carrot (Daucus carota subsp. sativus) and beetroot juice (Beta vulgaris)
Wybrane substancje bioaktywne pochodzenia roślinnego i ich rola w zapobieganiu nowotworom
Background. Cancer poses a major public health challenge. Cancer treatment is expensive, burdened with many side effects, and in the case of some types of cancer, ineffective. This is related to the high degree of complexity of metabolic disorders accompanying the growth of neoplastic tissue. Therefore, special attention is paid to primary prevention, the aim of which is to reduce the risk of disease. Primary prevention activities focus on reducing exposure to modifiable risk factors, which include e.g. smoking, alcohol consumption, low physical activity and poor diet. Results and conclusion. The paper presents literature reports on the protective effect of bioactive compounds of plant origin against the development of cancer. Individual groups of compounds such as fibre, stilbenes, carotenoids, glucosinolates, betalains, phytitians, flavonoids, isoflavones and anthocyanins were characterized. The anti-carcinogenic properties of bioactive ingredients are discussed, taking into account the molecular mechanisms underlying their action. Particular attention was paid to the sources of compounds with anticancer activity present in food and the way these substances act on the processes of growth and migration of cancer cells. In addition, the results of experiments using in vitro and in vivo models as well as case-control trials with human participants are presented.
An in vitro gastrointestinal model to evaluate the tolerance of encapsulated Lactobacillus and Lactococcus strains with synbiotic containing lactobionic acid via lyophilization technique to harsh gastric conditions during storage time
Rola żywienia i substancji bioaktywnych pochodzenia roślinnego w prewencji chorób nowotworowych
Background. Cancer is one of the leading causes of mortality worldwide. Carcinogenesis is a multistage and complex process that may be partially reversible. In the process of carcinogenesis, numerous metabolic pathways associated with normal cell growth and division are disturbed. An important role in the prevention of cancer is played by a lifestyle characterized by maintaining a healthy weight, an appropriate level of physical activity and increased consumption of food with anti-cancer properties. Results and conclusion. The paper presents the latest literature reports on the pathogenesis of cancer and the impact of diet on the risk of its occurrence. In addition, known models of carcinogenesis and their impact on the development of knowledge in the field of oncology are discussed. Current recommendations on nutrition in cancer prevention, developed by the American Cancer Research Fund, are also presented. The aim of this paper is also to present the role of selected bioactive components of plant origin in cancer prevention. The paper presents basic information on carcinogenesis and the dietary anticancerogen mechanisms . Individual groups of bioactive compounds showing anticancer activity are discussed: dietary fiber, phenolic compounds, flavonoid phytoestrogens (classified as phenolic compounds) and nonflavonoid compounds, betalains, glucosinolates, phytates and carotenoids. An attempt was made to systematize knowledge on the anticancer properties of these compounds. By altering the diet, the supply of plant-derived bioactive components should be increased, which, through various mechanisms, have the ability to inhibit various phases of tumor formation and reduce the supply of potential carcinogens.
Quantitative Analysis of Lactobionic Acid in Bioreactor Cultures and Selected Biological Activities
The aim of this study was to quantitatively analyse lactobionic acid obtained from bioreactor cultures using whey as a liquid medium with bacteria of the Pseudomonas taetrolens species. The most important culture parameters affecting the production of the acid are indicated and evaluated. The highest lactobionic acid yield was 37.42 g/L, selecting the appropriate strain (Pseudomonas taetrolens 4′) and environmental conditions (2% lactose concentration in the bioreactor). The amount of lactose and lactobionic acid was determined by high-performance liquid chromatography. Microorganism analysis was also carried out using a flow cytometer with imaging to study the metabolic activity of microorganisms during lactobionic acid production. In addition, during the study, Bifidobacteria were microencapsulated with lactobionic acid and their survival was evaluated in an in vitro model of the gastrointestinal tract, checking the prebiotic properties of the acid. The highest number of viable cells in the microcapsules after digestion was obtained using the Bifidobacterium bifidum strain DSM 20082. The antagonistic activity of lactobionic acid was also analysed.