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Serum lactoferrin levels in abdominal obese postmenopausal women with normal bone status and osteopenia

cris.lastimport.scopus2025-10-23T06:55:26Z
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cris.virtual.author-orcid0000-0002-2268-9326
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cris.virtualsource.author-orcid190a1224-971b-4b6e-a791-aa08ba93ca89
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cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground. Recently, it has been shown that lactoferrin intake might impact bone health. However, less is known about the association between blood lactoferrin levels and bone status. Therefore, this study aimed to compare serum lactoferrin concentrations between abdominally obese postmenopausal women with normal bone health and osteopenia. Material and methods. A total of 238 women aged 50–75 years with a body mass index (BMI) ≥ 30 kg/m2 and waist circumference ≥ 88 cm were included in the study. Their bone mineral density (BMD) and content (BMC) for the total body, lumbar spine and femoral neck were measured using the dual-energy X-ray absorptiometry method, and the T-score and Z-score were calculated. Biochemical markers of glucose and insulin homeostasis, lipid metabolism and inflammatory parameters, lactoferrin levels, and body composition were determined. Results. Women with a T-score of the lumbar spine > –1 were significantly younger (p = 0.0005) and had a higher body weight (p = 0.0208) and BMI (p = 0.0312) than participants with a T-score ≤ –1. In the group of subjects with a T-score > –1, BMC at the lumbar spine was significantly higher in women with lactoferrin levels below than above the median (p = 0.0455), whereas in the group of those with a T-score ≤ –1, women with lactoferrin levels lower than the median had significantly lower BMC (p = 0.0298), BMD (p = 0.0428), T-score (p = 0.0216) and Z-score (p = 0.0452) at the femoral neck and BMC (p = 0.0358), BMD (p = 0.0244) and T-score (p = 0.0139) at the total body. Conclusion. These results suggest that serum lactoferrin levels might be associated with bone health, but the effect may differ in subjects with normal bone status and osteopenia.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorJamka, Małgorzata
dc.contributor.authorMądry, Edyta
dc.contributor.authorKrzyżanowska-Jankowska, Patrycja
dc.contributor.authorBajerska, Joanna
dc.contributor.authorBogdański, Paweł
dc.contributor.authorLisowska, Aleksandra
dc.contributor.authorWalkowiak, Jarosław
dc.date.access2025-05-26
dc.date.accessioned2025-08-27T08:34:27Z
dc.date.available2025-08-27T08:34:27Z
dc.date.copyright2023-10-22
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,3
dc.description.number3
dc.description.points40
dc.description.versionfinal_published
dc.description.volume22
dc.identifier.doi10.17306/J.AFS.2023.1177
dc.identifier.eissn1898-9594
dc.identifier.issn1644-0730
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4416
dc.identifier.weblinkhttps://www.food.actapol.net/volume22/issue3/abstract-4.html
dc.languageen
dc.relation.ispartofActa Scientiarum Polonorum, Technologia Alimentaria
dc.relation.pages279-292
dc.rightsCC-BY-NC
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enlactoferrin
dc.subject.enobesity
dc.subject.endensitometry
dc.subject.enbone density
dc.subject.enwomen
dc.titleSerum lactoferrin levels in abdominal obese postmenopausal women with normal bone status and osteopenia
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.volume22