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Formylated Bile Acid–Steroid Conjugates: Synthesis, Antifungal Properties, and In Silico Studies

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cris.virtualsource.author-orcid1e124447-5576-474f-b662-b24f9118c42d
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dc.abstract.enFungal infections caused by Alternaria alternata, Fusarium culmorum (F. culmorum), and Botrytis cinerea (B. cinerea) pose significant risks to agriculture and human health. The emergence of fungicide resistance underscores the need for new antifungal agents. Bile acid−steroid conjugates, synthesized via “click chemistry”, offer a promising solution due to their stability and biological activity. In this study, bile acid derivatives linked by 1,2,3-triazole rings were synthesized and evaluated for antifungal activity. Spectroscopic analysis confirmed successful conjugation, and molecular docking studies identified interactions with fungal targets. Biological assays revealed potent antifungal effects, especially against F. culmorum and B. cinerea, with compounds (23) and (24) showing the strongest activity. These findings highlight the potential of bile acid derivatives as novel antifungal agents, and further optimization could enhance their efficacy and selectivity for therapeutic applications.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Gleboznawstwa i Mikrobiologii
dc.contributor.authorHajdaś, Grzegorz
dc.contributor.authorKułaga, Damian
dc.contributor.authorKoenig, Hanna
dc.contributor.authorStarzyk, Justyna
dc.contributor.authorMaliugin, Vladislav
dc.contributor.authorPospieszny, Tomasz
dc.date.access2025-12-10
dc.date.accessioned2025-12-10T07:57:57Z
dc.date.available2025-12-10T07:57:57Z
dc.date.copyright2025-12-03
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,3
dc.description.number49
dc.description.points70
dc.description.versionfinal_published
dc.description.volume10
dc.identifier.doi10.1021/acsomega.5c05320
dc.identifier.issn2470-1343
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6295
dc.identifier.weblinkhttp://pubs.acs.org/doi/10.1021/acsomega.5c05320
dc.languageen
dc.relation.ispartofACS Omega
dc.relation.pages60152-60161
dc.rightsCC-BY-NC-ND
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.titleFormylated Bile Acid–Steroid Conjugates: Synthesis, Antifungal Properties, and In Silico Studies
dc.typeJournalArticle
dspace.entity.typePublication