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Host Factors Associated with Gut Mycobiome Structure

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dc.abstract.enRecent studies revealed a significant role of the gut fungal community in human health. Here, we investigated the content and variation of gut mycobiota among subjects from the European population. We explored the interplay between gut fungi and various host-related sociodemographic, lifestyle, health, and dietary factors. The study included 923 participants. Fecal DNA samples were analyzed by whole-metagenome high-throughput sequencing. Subsequently, fungi taxonomic profiles were determined and accompanied by computational and statistical analyses of the association with 53 host-related factors. Fungal communities were characterized by a high prevalence of Saccharomyces, Candida, and Sporisorium. Ten factors were found to correlate significantly with the overall mycobiota variation. Most were diet related, including the consumption of chips, meat, sodas, sweetening, processed food, and alcohol, followed by age and marital status. Differences in α- and/or β-diversity were also reported for other factors such as body mass index (BMI), job type, autoimmunological diseases, and probiotics. Differential abundance analysis revealed fungal species that exhibited different patterns of changes under specific conditions. The human gut mycobiota is dominated by yeast, including Saccharomyces, Malassezia, and Candida. Although intervolunteer variability was high, several fungal species persisted across most samples, which may be evidence that a core gut mycobiota exists. Moreover, we showed that host-related factors such as diet, age, and marital status influence the variability of gut mycobiota. To our knowledge, this is the first large and comprehensive study of the European cohort in terms of gut mycobiota associations with such an extensive and differentiated host-related set of factors.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSzóstak, Natalia
dc.contributor.authorHandschuh, Luiza
dc.contributor.authorSamelak-Czajka, Anna
dc.contributor.authorTomela, Katarzyna
dc.contributor.authorSchmidt, Marcin
dc.contributor.authorPruss, Łukasz
dc.contributor.authorMilanowska-Zabel, Kaja
dc.contributor.authorKozlowski, Piotr
dc.contributor.authorPhilips, Anna
dc.date.access2025-08-04
dc.date.accessioned2025-08-06T10:21:08Z
dc.date.available2025-08-06T10:21:08Z
dc.date.copyright2023-02-14
dc.date.issued2023
dc.description.abstract<jats:p>The human gut is inhabited by many organisms, including bacteria and fungi, that may affect human health. However, research on human gut mycobiome is still rare.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,0
dc.description.number2
dc.description.points140
dc.description.versionfinal_published
dc.description.volume8
dc.identifier.doi10.1128/msystems.00986-22
dc.identifier.issn2379-5077
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4097
dc.identifier.weblinkhttps://journals.asm.org/doi/10.1128/msystems.00986-22
dc.languageen
dc.relation.ispartofmSystems
dc.relation.pagese00986-22
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.engut mycobiome
dc.subject.enintestinal microbiota
dc.subject.enhigh-throughput sequencing
dc.subject.entaxonomy profiling
dc.subject.enbioinformatics
dc.subject.ennext-generation sequencing
dc.titleHost Factors Associated with Gut Mycobiome Structure
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume8