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Morpholinium-based Ionic Liquids as Potent Antibiofilm and Sensitizing Agents for the Control of Pseudomonas aeruginosa

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cris.virtual.author-orcid0000-0003-3145-9407
cris.virtual.author-orcid0000-0003-3455-3044
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cris.virtualsource.author-orcid8da63665-4835-4e83-a6d3-28544e67b2b4
cris.virtualsource.author-orcid94301770-9c63-42ac-aa65-6e7718de55c1
cris.virtualsource.author-orcid789ea30a-f0af-454d-b257-827c734e8291
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dc.abstract.enRising antimicrobial resistance is a critical threat to worldwide public health. To address the increasing antibiotic tolerance, diverse antimicrobial agents are examined for their ability to decrease bacterial resistance. One of the most relevant and persistent human pathogens is Pseudomonas aeruginosa. Our study investigates the anti-biofilm and sensitizing activity of 12 morpholinium-based ionic liquids with herbicidal anions on four clinically relevant P. aeruginosa strains. Among all tested compounds, four ionic liquids prevented biofilm formation at sub-minimum inhibitory concentrations for all investigated strains. For the first time, we established a hormetic effect on biofilm formation for P. aeruginosa strains subjected to an ionic liquid treatment. Interestingly, while ionic liquids with 4,4-didecylmorpholinium [Dec2Mor]+ are more efficient against planktonic bacteria, 4-decyl-4-ethylmorpholinium [DecEtMor]+ showed more potent inhibition of biofilm formation. Ionic liquids with 4,4-didecylmorpholinium ([Dec2Mor]+) cations even induced biofilm formation by strain 39016 at high concentrations due to flocculation. Morpholinium-based ionic liquids were also shown to enhance the efficacy of commonly used antibiotics from different chemical groups. We demonstrate that this synergy is associated with the mode of action of the antibiotics.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Bioinżynierii
dc.affiliation.instituteKatedra Biochemii i Biotechnologii
dc.contributor.authorMichalski, Jakub
dc.contributor.authorCłapa, Tomasz
dc.contributor.authorNarożna, Dorota
dc.contributor.authorSyguda, Anna
dc.contributor.authorvan Oostrum, Peter
dc.contributor.authorReimhult, Erik
dc.date.accessioned2024-08-29T07:02:46Z
dc.date.available2024-08-29T07:02:46Z
dc.date.issued2024
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,7
dc.description.number13
dc.description.points140
dc.description.reviewreview
dc.description.volume436
dc.identifier.doi10.1016/j.jmb.2024.168627
dc.identifier.issn0022-2836
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1695
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/abs/pii/S0022283624002225
dc.languageen
dc.relation.ispartofJournal of Molecular Biology
dc.relation.pagesart. 168627
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enPseudomonas aeruginosa
dc.subject.enionic liquids
dc.subject.enbiofilm
dc.subject.enantimicrobial agents
dc.titleMorpholinium-based Ionic Liquids as Potent Antibiofilm and Sensitizing Agents for the Control of Pseudomonas aeruginosa
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue13
oaire.citation.volume436
project.funder.nameb.d.