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Structural diversity of salts of vitamin B6 with gentisic acid and the impact of a dihydrate form on antioxidant activity and boar sperm viability

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cris.virtual.author-orcid0000-0002-7642-0787
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cris.virtual.author-orcid0000-0001-6384-791X
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cris.virtualsource.author-orcid02a0d8c3-755b-4ed1-a428-3e47baa39519
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dc.abstract.enObtaining new pharmaceutical salts or cocrystals is a popular way to get compounds with better properties than their components. We report the synthesis of four different multi-component systems (I – IV) containing pyridoxine with gentisic acid (2,5-dihydroxybenzoic acid). Their crystal structures were studied by X-ray diffraction and FT-IR spectroscopy. Dihydrate form (IV), the easiest to obtain, was tested for antioxidant activity and preservation effects on boar sperm. Crystallization with gentisic acid significantly improved the free radicals scavenging ability of pyridoxine, increasing it more than three times. In vitro tests suggest that the supplementation of 2 or 4 mM solution of IV may support the quality of sperm cells, the observed effect is, however, breed-specific.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorBabijczuk, Karolina
dc.contributor.authorKomasa, Anna
dc.contributor.authorGołdyn, Mateusz
dc.contributor.authorBartoszak-Adamska, Elżbieta
dc.contributor.authorLarowska-Zarych, Daria
dc.contributor.authorLipińska, Paulina
dc.contributor.authorSell-Kubiak, Ewa
dc.contributor.authorWarzych-Plejer, Ewelina
dc.date.accessioned2025-08-29T12:37:43Z
dc.date.available2025-08-29T12:37:43Z
dc.date.issued2025
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,7
dc.description.number1, ( 25 December 2025)
dc.description.points70
dc.description.volume1348
dc.identifier.doi10.1016/j.molstruc.2025.143452
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4534
dc.languageen
dc.relation.ispartofJournal of Molecular Structure
dc.relation.pagesart. 143452
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enpyridoxine
dc.subject.engentisic acid
dc.subject.enpharmaceutical salts
dc.subject.enX-ray diffraction
dc.subject.ensperm quality
dc.titleStructural diversity of salts of vitamin B6 with gentisic acid and the impact of a dihydrate form on antioxidant activity and boar sperm viability
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume1348