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Impact of Dietary Salicylates on Iron, Zinc, and Copper Status in Preeclampsia Model Rats Induced by L-NAME

cris.lastimport.scopus2025-10-23T06:55:29Z
cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0003-4113-1595
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcide5b3bdcc-fb9a-4a83-9a35-c24812d69ccd
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enLow-dose aspirin prophylaxis is recommended for women at high risk of preeclampsia. It has been suggested that dietary salicylates may have a similar effect. Despite the known anti-inflammatory properties of salicylates, their influence on trace elements in preeclampsia remains unclear. This research investigated the effect of dietary salicylates and aspirin on iron, zinc, and copper status in rats with NG-nitro-L-arginine methyl ester (L-NAME)–induced preeclampsia. The study involved pregnant Sprague Dawley rats divided into six groups: control group (CH), preeclamptic rats (CP), preeclamptic rats with a low dose of dietary salicylate (LSP), preeclamptic rats with a high dose of dietary salicylate, preeclamptic rats with a low dose of aspirin (LAP), and preeclamptic rats with a high dose of aspirin. The content of trace elements in diets, liver, kidney, heart, spleen, pancreas, femur, brain, and hair was measured using flame atomic absorption spectrometry. Salicylate concentrations in diets, serum, and urine were analyzed using HPLC and UHPLC-MS/MS systems. Administration of L-NAME resulted in elevated blood pressure across groups, and only the LAP group had blood pressure levels comparable to the CH group. Preeclampsia significantly decreased serum hepcidin levels, while salicylates abolished this effect. Salicylate administration significantly decreased iron levels in hair and increased maternal zinc concentrations in the brain. Dietary salicylates markedly increased zinc levels in the placenta. In conclusion, L-NAME–induced preeclampsia decreases maternal serum hepcidin. Treatment with salicylates modulates iron and zinc status in preeclamptic rats, with specific effects on hepcidin levels.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Chemii
dc.contributor.authorCholik, Rafsan Syabani
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorWaśkiewicz, Agnieszka
dc.contributor.authorKaraźniewicz-Łada, Marta
dc.contributor.authorSuliburska, Joanna
dc.date.access2025-08-13
dc.date.accessioned2025-08-14T05:51:49Z
dc.date.available2025-08-14T05:51:49Z
dc.date.copyright2025-08-07
dc.date.issued2025
dc.description.abstract<jats:title>Abstract</jats:title> <jats:p>Low-dose aspirin prophylaxis is recommended for women at high risk of preeclampsia. It has been suggested that dietary salicylates may have a similar effect. Despite the known anti-inflammatory properties of salicylates, their influence on trace elements in preeclampsia remains unclear. This research investigated the effect of dietary salicylates and aspirin on iron, zinc, and copper status in rats with NG-nitro-L-arginine methyl ester (L-NAME)–induced preeclampsia. The study involved pregnant Sprague Dawley rats divided into six groups: control group (CH), preeclamptic rats (CP), preeclamptic rats with a low dose of dietary salicylate (LSP), preeclamptic rats with a high dose of dietary salicylate, preeclamptic rats with a low dose of aspirin (LAP), and preeclamptic rats with a high dose of aspirin. The content of trace elements in diets, liver, kidney, heart, spleen, pancreas, femur, brain, and hair was measured using flame atomic absorption spectrometry. Salicylate concentrations in diets, serum, and urine were analyzed using HPLC and UHPLC-MS/MS systems. Administration of L-NAME resulted in elevated blood pressure across groups, and only the LAP group had blood pressure levels comparable to the CH group. Preeclampsia significantly decreased serum hepcidin levels, while salicylates abolished this effect. Salicylate administration significantly decreased iron levels in hair and increased maternal zinc concentrations in the brain. Dietary salicylates markedly increased zinc levels in the placenta. In conclusion, L-NAME–induced preeclampsia decreases maternal serum hepcidin. Treatment with salicylates modulates iron and zinc status in preeclamptic rats, with specific effects on hepcidin levels. </jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.versionfinal_published
dc.identifier.doi10.1007/s12011-025-04772-1
dc.identifier.eissn1559-0720
dc.identifier.issn0163-4984
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4217
dc.identifier.weblinkhttps://link.springer.com/article/10.1007/s12011-025-04772-1
dc.languageen
dc.relation.ispartofBiological Trace Element Research
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subtypeArticleEarlyAccess
dc.titleImpact of Dietary Salicylates on Iron, Zinc, and Copper Status in Preeclampsia Model Rats Induced by L-NAME
dc.typeJournalArticle
dspace.entity.typePublication