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Berberine and its derivatives in collagen matrices as antimicrobial agents

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cris.virtual.author-orcid0000-0003-0569-3312
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cris.virtualsource.author-orcid5a53bc3c-681d-423e-8725-b38256509512
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dc.abstract.enThe combination of collagen with natural plant compounds confers anti-inflammatory, antimicrobial, and antiviral activities to the polymeric material. These favorable properties enable broad-spectrum application of traditional, natural polymers in biomedicine. In the present study, natural fish collagen was combined with commercially available berberine (BBR) and naturally occurring protoberberine alkaloids obtained from the medicinal herb Chelidonium majus L (BBR-F). The incorporation of plant constituents into collagen matrices was confirmed by Raman spectroscopy. The antimicrobial properties of the plant-polymeric composites were assessed against typical pathogenic microorganisms (Staphylococcus aureus, Escherichia coli, Candida albicans). The plant-based collagen matrices inhibited the growth of all the studied pathogens.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Fizyki i Biofizyki
dc.contributor.authorWarowicka, Alicja
dc.contributor.authorKościński, Mikołaj
dc.contributor.authorWaszczyk, Maciej
dc.contributor.authorGoździcka-Józefiak, Anna
dc.date.access2026-03-11
dc.date.accessioned2026-03-23T13:45:43Z
dc.date.available2026-03-23T13:45:43Z
dc.date.copyright2022-05-16
dc.date.issued2022
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The combination of collagen with natural plant compounds confers anti-inflammatory, antimicrobial, and antiviral activities to the polymeric material. These favorable properties enable broad-spectrum application of traditional, natural polymers in biomedicine. In the present study, natural fish collagen was combined with commercially available berberine (BBR) and naturally occurring protoberberine alkaloids obtained from the medicinal herb <jats:italic>Chelidonium majus</jats:italic> L (BBR-F). The incorporation of plant constituents into collagen matrices was confirmed by Raman spectroscopy. The antimicrobial properties of the plant-polymeric composites were assessed against typical pathogenic microorganisms (<jats:italic>Staphylococcus aureus</jats:italic>, <jats:italic>Escherichia coli</jats:italic>, <jats:italic>Candida albicans)</jats:italic>. The plant-based collagen matrices inhibited the growth of all the studied pathogens.</jats:p> <jats:p><jats:bold>Graphical abstract</jats:bold></jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,9
dc.description.number3
dc.description.points100
dc.description.versionfinal_published
dc.description.volume12
dc.identifier.doi10.1557/s43579-022-00181-w
dc.identifier.issn2159-6867
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7889
dc.identifier.weblinkhttp://link.springer.com/article/10.1557/s43579-022-00181-w
dc.languageen
dc.relation.ispartofMRS Communications
dc.relation.pages336-342
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subject.enbiomaterial
dc.subject.enbiomedical
dc.subject.enpolymer
dc.subject.endegradable
dc.subject.entoxicity
dc.titleBerberine and its derivatives in collagen matrices as antimicrobial agents
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue3
oaire.citation.volume12