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Assessment of the effectiveness and safety of two-month oral supplementation with l-arginine depending on the type of lipid metabolism disorder in patients with atherosclerotic lower limb ischemia.

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dc.abstract.enLower limb arterial disease is among the most common vascular disorders, with its incidence rising significantly in aging populations, thus posing a major social and healthcare challenge. Currently, L-arginine is considered by vascular surgery experts as a compound with therapeutic potential in intermittent claudication, though its clinical efficacy remains insufficiently confirmed. The aim of this study was to evaluate the efficacy and safety of oral L-arginine supplementation in patients with atherosclerotic lower limb ischemia, with particular regard to lipid metabolism disorders. A randomized study included 100 patients (62 men and 38 women) over 50 years of age with Fontaine stage II ischemia. The study group received oral L-arginine at a dose of 6 g/day for 30 and 60 days. Clinical parameters were assessed, including the ankle-brachial index (ABI) and pain-free walking distance (PFWD), along with oxidative stress markers (serum nitric oxide (NO) concentration, total antioxidant status (TAS)) and lipid profile (total, HDL, and LDL cholesterol, and triglycerides). In both study and control groups, subgroups with hypertriglyceridemia, hypercholesterolemia, and mixed hyperlipidemia were additionally identified. Evaluations were performed at baseline, day 30, and day 60. After 30 and 60 days, significant increases in NO and TAS levels (p
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.contributor.authorM. Micker
dc.contributor.authorN. Balcer-Dymel
dc.contributor.authorM. Czerwonka
dc.contributor.authorB. Madej
dc.contributor.authorE. Swiecka
dc.contributor.authorKołodziejski, Paweł
dc.contributor.authorPruszyńska-Oszmałek, Ewa
dc.contributor.authorZ. Checinska-Maciejewska
dc.contributor.authorH. Krauss
dc.contributor.authorA. Rekas-Dudziak
dc.date.access2025
dc.date.accessioned2025-12-10T10:45:05Z
dc.date.available2025-12-10T10:45:05Z
dc.date.copyright2025-10-31
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,7
dc.description.number5
dc.description.points100
dc.description.versionfinal_published
dc.description.volume76
dc.identifier.doi10.26402/jpp.2025.5.05
dc.identifier.eissn1899-1505
dc.identifier.issn0867-5910
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6320
dc.identifier.weblinkhttps://www.jpp.krakow.pl
dc.languageen
dc.relation.ispartofJournal of Physiology and Pharmacology
dc.relation.pages535-546
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enL-arginine
dc.subject.ennitric oxide
dc.subject.enlower limb arterial disease
dc.subject.enhypertriglyceridemia
dc.subject.enhypercholesterolemia
dc.subject.entotal antioxidant status
dc.titleAssessment of the effectiveness and safety of two-month oral supplementation with l-arginine depending on the type of lipid metabolism disorder in patients with atherosclerotic lower limb ischemia.
dc.typeJournalArticle
dspace.entity.typePublication