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Zein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential

cris.virtual.author-orcid0000-0002-0120-2734
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cris.virtualsource.author-orcid44370511-a743-43d2-9522-1c489f4cabcf
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dc.abstract.enHesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability—this research aimed to develop a zein-based hesperidin system with increased solubility and a sustained release profile. The study used triple systems enriched with solubilizers to maximize solubility. The best system was the triple system hesperidin-zein-Hpβ-CD, for which the solubility improved by more than six times. A significant improvement in the antioxidant activity and the ability to inhibit α-glucosidase was also demonstrated, due to an improved solubility. A release profile analysis was performed in the subsequent part of the experiments, confirming the sustained release profile of hesperidin, while improving the solubility. Moreover, the ability of selected probiotic bacteria to metabolize hesperidin and the effect of this flavonoid compound on their growth were investigated.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSip, Szymon
dc.contributor.authorSip, Anna
dc.contributor.authorMiklaszewski, Andrzej
dc.contributor.authorŻarowski, Marcin
dc.contributor.authorCielecka-Piontek, Judyta
dc.date.access2025-08-07
dc.date.accessioned2025-08-07T06:44:13Z
dc.date.available2025-08-07T06:44:13Z
dc.date.copyright2023-07-04
dc.date.issued2023
dc.description.abstract<jats:p>Hesperidin is a polyphenol derived from citrus fruits that has a broad potential for biological activity and the ability to positively modify the intestinal microbiome. However, its activity is limited by its low solubility and, thus, its bioavailability—this research aimed to develop a zein-based hesperidin system with increased solubility and a sustained release profile. The study used triple systems enriched with solubilizers to maximize solubility. The best system was the triple system hesperidin-zein-Hpβ-CD, for which the solubility improved by more than six times. A significant improvement in the antioxidant activity and the ability to inhibit α-glucosidase was also demonstrated, due to an improved solubility. A release profile analysis was performed in the subsequent part of the experiments, confirming the sustained release profile of hesperidin, while improving the solubility. Moreover, the ability of selected probiotic bacteria to metabolize hesperidin and the effect of this flavonoid compound on their growth were investigated.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,2
dc.description.number13
dc.description.points140
dc.description.versionfinal_published
dc.description.volume28
dc.identifier.doi10.3390/molecules28135209
dc.identifier.issn1420-3049
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4105
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/28/13/5209
dc.languageen
dc.relation.ispartofMolecules
dc.relation.pagesart. 5209
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enhesperidin
dc.subject.enzein
dc.subject.enextended-release
dc.subject.enimproved solubility
dc.subject.enmicrobiome
dc.subject.enLactiplantibacillus
dc.titleZein as an Effective Carrier for Hesperidin Delivery Systems with Improved Prebiotic Potential
dc.title.volumeSpecial Issue Bioactive Compounds from Medicinal Plants, Plant-Based Foods and Functional Foods: Advances and Opportunities
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue13
oaire.citation.volume28