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Tolerance of Biopronil Spot on after repeated single- or multiple-dose topical treatments in dogs

cris.virtual.author-orcid0000-0002-4509-8852
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cris.virtual.author-orcid0000-0003-2220-2730
cris.virtual.author-orcid0000-0002-4563-3798
cris.virtualsource.author-orcid702c3b7e-b378-411f-bc9b-510fe73f43da
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cris.virtualsource.author-orcid71dccebf-e765-40b9-87bb-e98ab3b7299c
cris.virtualsource.author-orcid2887b0c9-4f57-4235-a68f-057f9a3211f9
dc.abstract.enA variety of toxic effects of fipronil (FIP), the active substance of Biopronil Spot on®, on animals and humans has been reported and raises the need to investigate the FIP toxic effects. The objectives of the study were the evaluation of the local and systemic tolerance of Biopronil Spot on® and the assessment of its influence on haematological and biochemical blood parameters after single and multiple topical treatment in dogs. Thirtytwo mixed breed dogs were included in the study assessing the local and general tolerance of Biopronil Spot on® following single, triple and fivefold dose after spot-on multiple applications in dogs (on days 0, +28 and +56) at a dosage 134 mg for a dog weighing 10–20 kg and 268 mg for a dog weighing 21–40 kg. A physical examination and biochemical and haematological analyses were performed on the days of the study as follows: –14, –5, +3, +31, +59, +70. No visible pathological changes on the skin were observed. The biochemical and haematological indicators rarely exceeded the reference values. No influence of Biopronil Spot on® administered in single, triple and fivefold repeated doses on the assessed clinical, haematological and biochemical parameters in dogs was found under the conditions described in the study.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.contributor.authorTurlewicz-Podbielska, Hanna
dc.contributor.authorKowalski, Cezary Jacek
dc.contributor.authorBurmanczuk, Artur
dc.contributor.authorVynjarska, Alla
dc.contributor.authorWojciechowski, Jaroslaw
dc.contributor.authorPomorska-Mól, Małgorzata
dc.contributor.authorRybska, Marta
dc.date.access2026-02-06
dc.date.accessioned2026-02-23T13:42:14Z
dc.date.available2026-02-23T13:42:14Z
dc.date.copyright2022-05-19
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if0,7
dc.description.number8
dc.description.points70
dc.description.versionfinal_published
dc.description.volume67
dc.identifier.doi10.17221/6/2021-VETMED
dc.identifier.eissn1805-9392
dc.identifier.issn0375-8427
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7435
dc.identifier.weblinkhttps://vetmed.agriculturejournals.cz/artkey/vet-202208-0003_tolerance-of-biopronil-spot-on-174-after-repeated-single-or-multiple-dose-topical-treatments-in-dogs.php
dc.languageen
dc.relation.ispartofVeterinární medicína
dc.relation.pages418-429
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enadverse effects
dc.subject.enbiochemical indicators
dc.subject.enfipronil
dc.subject.enhaematological indicators
dc.subject.ensubstance-related disorders
dc.titleTolerance of Biopronil Spot on after repeated single- or multiple-dose topical treatments in dogs
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue8
oaire.citation.volume67