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Determination of antidiabetic activity of steviol glycosides by evaluation of α-glucosidase inhibition in vitro

cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
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cris.virtual.author-orcid0000-0002-4399-7459
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cris.virtualsource.author-orcid10fdded3-5140-4fbe-80bb-03575e77544c
dc.abstract.enStevia and its glycosides are becoming increasingly popular due to their health-promoting properties, such as anti-inflammatory, oral health-promoting, antihypertensive and antidiabetic potential. As the mechanisms underlying the antidiabetic effects of steviol glycosides have not been fully understood, they require further investigation. This study aimed to evaluate the antidiabetic activity of steviol glycosides (stevioside and rebaudioside A) in terms of α-glucosidase inhibition using the spectrophotometric method. It was found that stevioside and rebaudioside A exhibit weak antidiabetic potential through the mechanism of α-glucosidase inhibition. Stevioside (IC50 = 81.11 mg/mL) was shown to have stronger activity compared with rebaudioside A (IC50 = 257.55 mg/mL), but weaker compared with acarbose (IC50 = 1.67 mg/mL).
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorKurek, Jakub Michał
dc.contributor.authorGościniak, Anna
dc.contributor.authorCielecka-Piontek, Judyta
dc.contributor.authorKrejpcio, Zbigniew
dc.contributor.editorBernaś, Emilia
dc.contributor.editorGałkowska, Dorota
dc.contributor.editorTopolska, Kinga
dc.date.accessioned2025-12-17T07:44:35Z
dc.date.available2025-12-17T07:44:35Z
dc.date.issued2023
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.identifier.isbn978-83-953897-5-7
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6421
dc.languageen
dc.pubinfoKraków
dc.publisher.ministerialWydawnictwo Naukowe PTTŻ
dc.relation.bookŻywność jako wyzwanie dla współczesnej nauki i przemysłu
dc.relation.pages194-204
dc.relation.projectDNK/SP/549771/2022
dc.sciencecloudnosend
dc.subject.enstevioside
dc.subject.enrebaudioside A
dc.subject.enantidiabetic activity
dc.subject.enα-glucosidase inhibition
dc.titleDetermination of antidiabetic activity of steviol glycosides by evaluation of α-glucosidase inhibition in vitro
dc.typeMonographChapter
dspace.entity.typePublication