Simple item page
 

Maternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner

cris.virtual.author-orcid0000-0002-8798-991X
cris.virtual.author-orcid0000-0003-4560-0723
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0001-6981-9653
cris.virtualsource.author-orcid7d619370-fc16-4ebc-8bfa-6738a36749ee
cris.virtualsource.author-orcid234d7d6f-1f21-4447-805c-c6e107f13605
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid86de7053-c0cc-4a23-960c-fd3908659acc
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid06d96226-5dc5-4667-a85b-254ac606fda1
dc.abstract.enBackground An unhealthy diet contributes significantly to the development of the global obesity epidemic and serves as a risk factor for fertility disorders. Moreover, maternal obesity leads to alterations in the reproductive capacity of the offspring via prenatal and postnatal programming. Methods To replicate the impact of a diet rich in sugar and fat, which contributes to human obesity, we utilized a cafeteria (CAF) diet in rat mothers to investigate molecular and morphological consequences in the gonads of male and female progeny. Rat mothers were fed either standard (control) or CAF diet before and during pregnancy and lactation. Female and male offspring were sacrificed after weaning at different stages of reproductive maturation—females on postnatal days (PNDs) 30, 35, and 60, and males on PNDs 40 and 60. Ovaries and testis were examined for the expression of the kisspeptin system, including Kiss1, Kiss1r, estrogen (Esr1, Esr2), androgen (Ar), and luteinizing hormone choriogonadotropin (Lhcgr) receptors. Additionally, morphological parameters of the ovaries and testes were evaluated. Results Male offspring of CAF mothers showed: i) alterations in Ar and Kiss1 mRNA levels, and ii) decreased seminiferous tubules diameter and epithelium height, a reduced number of Sertoli cells, a lower percentage of seminiferous tubules with presented spermatozoa. Female offspring of CAF mothers exhibited: i) disturbed expression of Esr1, Esr2, Ar, and Lhcgr receptors in the ovaries, and ii) a diminished number of primordial and secondary follicles at PND 30 and primary follicles at PND 35. Conclusions We concluded that the maternal CAF diet leads to sex-specific alterations in the reproductive parameters of offspring.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.affiliation.instituteKatedra Zoologii
dc.contributor.authorGrzęda, Emilia
dc.contributor.authorGutkowska-Kawka, Dominika
dc.contributor.authorMatuszewska, Julia
dc.contributor.authorKilańczyk, Ewa
dc.contributor.authorKaczmarek, Monika M.
dc.contributor.authorDylewski, Łukasz
dc.contributor.authorŚliwowska, Joanna Helena
dc.date.access2025-08-01
dc.date.accessioned2025-08-01T11:33:55Z
dc.date.available2025-08-01T11:33:55Z
dc.date.copyright2025-05-26
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_act
dc.description.financecost15885,9
dc.description.if4,7
dc.description.points140
dc.description.versionfinal_published
dc.description.volume23
dc.identifier.doi10.1186/s12958-025-01412-0
dc.identifier.issn1477-7827
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4050
dc.identifier.weblinkhttps://rbej.biomedcentral.com/articles/10.1186/s12958-025-01412-0
dc.languageen
dc.pbn.affiliationbiological sciences
dc.relation.ispartofReproductive Biology and Endocrinology
dc.relation.pagesart. 79
dc.relation.projectThe publication was financed by the Polish Minister of Science and Higher Education as part of the Strategy of the Poznan University of Life Sciences for 2024-2026 in the field of improving scientific research and development work in priority research areas.
dc.rightsCC-BY-NC-ND
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enprenatal programming
dc.subject.enobesity
dc.subject.encafeteria diet
dc.subject.enovaries
dc.subject.entestes
dc.subject.enfertility
dc.subject.enkisspeptin
dc.titleMaternal cafeteria diet adversely affects the reproductive parameters of rat offspring in a sex-specific manner
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume23
project.funder.nameThe publication was financed by the Polish Minister of Science and Higher Education as part of the Strategy of the Poznan University of Life Sciences for 2024-2026 in the field of improving scientific research and development work in priority research areas.