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β-glucuronidase activity is associated with carbohydrate metabolism but not with androgen status in overweight and obese women with polycystic ovary syndrome

cris.virtual.author-orcid0000-0003-1996-5198
cris.virtual.author-orcid0000-0002-7402-1328
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-4731-6243
cris.virtual.author-orcid0000-0002-2045-0709
cris.virtual.author-orcid0000-0001-8417-2245
cris.virtualsource.author-orcid1ccb8edd-cf11-49a4-bd1c-af5fd753fdc7
cris.virtualsource.author-orcid59851afa-3d5d-435f-95ee-4130cbd454a0
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidd951fe7e-3886-48a5-8661-b05d0c844622
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
cris.virtualsource.author-orcidedf63522-bb89-4788-a8d3-9c3f3858875b
dc.abstract.enObjectives: The aim of this study was to evaluate the relationship between b-glucuronidase and androgen levels in overweight and obese women with polycystic ovary syndrome (PCOS). The connection between b-glucuronidase, the abundance of selected gut bacteria, carbohydrate metabolism, and diet quality was also determined. Methods: This cross-sectional study was conducted with 56 women with a mean age of 29.14 § 5.11 y and a mean body mass index (BMI) of 34.15 § 5.72 kg/m2 . Anthropometrical parameters, fecal b-glucosidase activity, and selected food frequency intake were measured. Results: Women with better quality diets, apart from lower BMI and better carbohydrate metabolism parameters, had more abundant Faecalibacterium prausnitzii and Akkermansia muciniphila. Two-hour oral glucose tolerance test (OGTT-2h-glu; mg/dL) was the main predictor of b-glucuronidase activity and there was no relationship between b-glucuronidase activity and androgen levels. Non-Healthy Diet Index-14 (nHDI-14) was the main predictor for A. muciniphila, Bifidobacteriu. longum, and F. prausnitzii abundance. QUICKI was a significant predictor of A. muciniphila abundance and OGTT-2h-glu was a significant predictor of F. prausnitzii abundance. Conclusion: There was no relationship between b-glucuronidase activity and androgen levels in overweight and obese women with PCOS, but b-glucuronidase activity may be an important factor in carbohydrate metabolism. Modulation of the abundances of F. prausnitzii, A. muciniphila, and B. longum using special diets should thus be considered a promising intervention.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorŁagowska, Karolina
dc.contributor.authorMalinowska, Anna Maria
dc.contributor.authorKapczuk, Karina
dc.contributor.authorMikołajczyk-Stecyna, Joanna
dc.contributor.authorChmurzyńska, Agata
dc.contributor.authorSchmidt, Marcin
dc.date.accessioned2026-03-30T11:22:14Z
dc.date.available2026-03-30T11:22:14Z
dc.date.issued2022
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,4
dc.description.numberMay 2022
dc.description.points140
dc.description.volume97
dc.identifier.doi10.1016/j.nut.2022.111606
dc.identifier.eissn1873-1244
dc.identifier.issn0899-9007
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7983
dc.languageen
dc.relation.ispartofNutrition
dc.relation.pagesart. 111606
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enpolycystic ovary syndrome
dc.subject.enobesity
dc.subject.enmicrobiome
dc.subject.enbeta-glucuronidase
dc.titleβ-glucuronidase activity is associated with carbohydrate metabolism but not with androgen status in overweight and obese women with polycystic ovary syndrome
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume97