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Ocimum basilicum L. extract-loaded liposomes ameliorate metribuzin-induced pulmonary and cardiac dysfunction in Wistar Albino rats

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cris.virtual.author-orcid0000-0002-8011-9487
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cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
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cris.virtualsource.author-orcid20597688-8be2-4b58-9e15-29f5ff8c53aa
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dc.abstract.enThe objective was to develop liposomes as a new drug delivery system (NDDS) containing basil extract and to investigate their therapeutic and protective effects against toxicity caused by exposure to metribuzin in the lungs and heart. For in vivo study, 24 male albino Wistar rats were divided into four groups (n = 6), control group, metribuzin-treated group, Basil extract-treated group (BE) and Basil extract liposomes-treated group (BE-LPs). The weight gain of each organ was measured. Superoxide dismutase (SOD), Glutathion peroxidase (GPx), Glutation S transferase (GSTs), Catalase (CAT), Reduced Glutathion (GSH) and malondialdehyde (MDA) levels in lugs and heart were measured in order to evaluate oxidative stress status. The tissue histology of the organs was examined. Various biochemical parameters and inflammation markers were estimated. Results of the in vivo rats' study showed that treatment with metribuzin induced increase in organs weight, oxidative stress, biochemical toxicity, inflammation, and histological changes in the lungs and heart, as well as a significant amelioration of BE and BE-LPs against the toxic effects induced by metribuzin by reversing all of the previous parameters. In conclusion, the application of BE-LPs appears to be effective in addressing the issues of oxidative stress and inflammation caused by metribuzin in the lungs and heart.
dc.abstract.languagept
dc.abstract.otherO objetivo foi desenvolver lipossomas como um novo sistema de liberação de medicamentos (NDDS) contendo extrato de manjericão e investigar seus efeitos terapêuticos e protetores contra a toxicidade causada pela exposição à metribuzina nos pulmões e no coração. Para o estudo in vivo, 24 ratos albinos Wistar machos foram divididos em quatro grupos (n = 6): grupo de controle, grupo tratado com metribuzina, grupo tratado com extrato de manjericão (BE) e grupo tratado com lipossomas de extrato de manjericão (BE-LPs). O ganho de peso de cada órgão foi medido. Os níveis de superóxido dismutase (SOD), glutationa peroxidase (GPx), glutationa S transferase (GSTs), catalase (CAT), glutationa reduzida (GSH) e malondialdeído (MDA) nos pulmões e no coração foram medidos para avaliar o estado de estresse oxidativo. A histologia dos tecidos dos órgãos foi examinada. Vários parâmetros bioquímicos e marcadores de inflamação foram estimados. Os resultados do estudo in vivo com ratos mostraram que o tratamento com metribuzina induziu o aumento do peso dos órgãos, estresse oxidativo, toxicidade bioquímica, inflamação e alterações histológicas nos pulmões e no coração, bem como uma melhora significativa das BE e BE-LPs contra os efeitos tóxicos induzidos pela metribuzina, revertendo todos os parâmetros anteriores. Em conclusão, a aplicação de BE-LPs parece ser eficaz na abordagem dos problemas de estresse oxidativo e inflamação causados pela metribuzina nos pulmões e no coração.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Biotechnologii
dc.affiliation.instituteKatedra Genetyki i Hodowli Roślin
dc.contributor.authorBoulaares, Islam
dc.contributor.authorDerouiche, Samir
dc.contributor.authorChetehouna, Sara
dc.contributor.authorNiemann, Janetta
dc.date.access2025-08-08
dc.date.accessioned2025-08-08T07:32:14Z
dc.date.available2025-08-08T07:32:14Z
dc.date.copyright2025-03-14
dc.date.issued2025
dc.description.abstract<jats:p>The objective was to develop liposomes as a new drug delivery system (NDDS) containing basil extract and to investigate their therapeutic and protective effects against toxicity caused by exposure to metribuzin in the lungs and heart. For in vivo study, 24 male albino Wistar rats were divided into four groups (n = 6), control group, metribuzin-treated group, Basil extract-treated group (BE) and Basil extract liposomes-treated group (BE-LPs). The weight gain of each organ was measured. Superoxide dismutase (SOD), Glutathion peroxidase (GPx), Glutation S transferase (GSTs), Catalase (CAT), Reduced Glutathion (GSH) and malondialdehyde (MDA) levels in lugs and heart were measured in order to evaluate oxidative stress status. The tissue histology of the organs was examined. Various biochemical parameters and inflammation markers were estimated. Results of the in vivo rats' study showed that treatment with metribuzin induced increase in organs weight, oxidative stress, biochemical toxicity, inflammation, and histological changes in the lungs and heart, as well as a significant amelioration of BE and BE-LPs against the toxic effects induced by metribuzin by reversing all of the previous parameters. In conclusion, the application of BE-LPs appears to be effective in addressing the issues of oxidative stress and inflammation caused by metribuzin in the lungs and heart.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.number1
dc.description.points5
dc.description.versionfinal_published
dc.description.volume6
dc.identifier.doi10.54021/seesv6n1-028
dc.identifier.issn2764-0981
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4111
dc.identifier.weblinkhttps://ojs.studiespublicacoes.com.br/ojs/index.php/sees/article/view/14762
dc.languageen
dc.language.otherpt
dc.pbn.affiliationagriculture and horticulture
dc.relation.ispartofStudies in Engineering and Exact Sciences
dc.relation.pagese14762
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enOcimum basilicum L.
dc.subject.enliposomes
dc.subject.enencapsulation
dc.subject.enmetribuzin
dc.subject.enlungs
dc.subject.enheart
dc.subject.languagept
dc.subject.otherOcimum basilicum L.
dc.subject.otherlipossomos
dc.subject.otherencapsulamento
dc.subject.othermetribuzina
dc.subject.otherpulmões
dc.subject.othercoração
dc.titleOcimum basilicum L. extract-loaded liposomes ameliorate metribuzin-induced pulmonary and cardiac dysfunction in Wistar Albino rats
dc.title.alternativeOs lipossomas carregados com extrato de Ocimum basilicumL. melhoram a disfunção cardíaca e pulmonar induzida pela metribuzina em ratos albinos Wistar
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume6