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Long term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics

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cris.virtual.author-orcid0000-0003-2085-038X
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cris.virtualsource.author-orcid804f2284-09e4-4ec9-a0c2-7f630d2a138c
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dc.abstract.enMajor histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency-dependent selection (NFDS), resulting from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained elusive. In particular, differentiation of NFDS from fluctuating selection, resulting from changes in parasite communities in time and space (FS), has proved difficult in short-term studies. Here, we used temporal data, accumulated through long-term monitoring of helminths infecting bank voles (Myodes glareolus), to test specific predictions of NFDS on MHC class II. Data were collected in three, moderately genetically differentiated subpopulations in Poland, which were characterized by some stable spatiotemporal helminth communities but also events indicating introduction of new species and loss of others. We found a complex association between individual MHC diversity and species richness, where intermediate numbers of DRB supertypes correlated with lowest species richness, but the opposite was true for DQB supertypes—arguing against universal selection for immunogenetic optimality. We also showed that particular MHC supertypes explain a portion of the variance in prevalence and abundance of helminths, but this effect was subpopulation-specific, which is consistent with both NFDS and FS. Finally, in line with NFDS, we found that certain helminths that have recently colonized or spread in a given subpopulation, more frequently or intensely infected voles with MHC supertypes that have been common in the recent past. Overall, our results highlight complex spatial and temporal patterns of MHC-parasite associations, the latter being consistent with Red Queen coevolutionary dynamics.
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Entomologii i Fitopatologii Leśnej
dc.contributor.authorMigalska, Magdalena
dc.contributor.authorPrzesmycka, Karolina
dc.contributor.authorAlsarraf, Mohammed
dc.contributor.authorBajer, Anna
dc.contributor.authorBehnke-Borowczyk, Jolanta
dc.contributor.authorGrzybek, Maciej
dc.contributor.authorBehnke, Jerzy M.
dc.contributor.authorRadwan, Jacek
dc.date.access2026-01-14
dc.date.accessioned2026-01-14T11:17:57Z
dc.date.available2026-01-14T11:17:57Z
dc.date.copyright2022-05-05
dc.date.issued2022
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Major histocompatibility complex (MHC) genes encode proteins crucial for adaptive immunity of vertebrates. Negative frequency‐dependent selection (NFDS), resulting from adaptation of parasites to common MHC types, has been hypothesized to maintain high, functionally relevant polymorphism of MHC, but demonstration of this relationship has remained elusive. In particular, differentiation of NFDS from fluctuating selection, resulting from changes in parasite communities in time and space (FS), has proved difficult in short‐term studies. Here, we used temporal data, accumulated through long‐term monitoring of helminths infecting bank voles (<jats:italic>Myodes glareolus</jats:italic>), to test specific predictions of NFDS on MHC class II. Data were collected in three, moderately genetically differentiated subpopulations in Poland, which were characterized by some stable spatiotemporal helminth communities but also events indicating introduction of new species and loss of others. We found a complex association between individual MHC diversity and species richness, where intermediate numbers of DRB supertypes correlated with lowest species richness, but the opposite was true for DQB supertypes—arguing against universal selection for immunogenetic optimality. We also showed that particular MHC supertypes explain a portion of the variance in prevalence and abundance of helminths, but this effect was subpopulation‐specific, which is consistent with both NFDS and FS. Finally, in line with NFDS, we found that certain helminths that have recently colonized or spread in a given subpopulation, more frequently or intensely infected voles with MHC supertypes that have been common in the recent past. Overall, our results highlight complex spatial and temporal patterns of MHC‐parasite associations, the latter being consistent with Red Queen coevolutionary dynamics.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,9
dc.description.number12
dc.description.points140
dc.description.versionfinal_published
dc.description.volume31
dc.identifier.doi10.1111/mec.16486
dc.identifier.eissn1365-294X
dc.identifier.issn0962-1083
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6809
dc.identifier.weblinkhttp://onlinelibrary.wiley.com/doi/10.1111/mec.16486
dc.languageen
dc.relation.ispartofMolecular Ecology
dc.relation.pages3400-3415
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOTHER
dc.subject.enmajor histocompatibility complex
dc.subject.enMyodes glareolus
dc.subject.ennegative frequency- dependent selection
dc.subject.enRed Queen
dc.titleLong term patterns of association between MHC and helminth burdens in the bank vole support Red Queen dynamics
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue12
oaire.citation.volume31