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Expression of genes encoding galectin-1 and galectin-9 in placentas of pregnancies with preterm prelabor rupture of membranes

cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-4731-6243
cris.virtual.author-orcid0000-0002-2045-0709
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidd951fe7e-3886-48a5-8661-b05d0c844622
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enObjectives: This study aims to elucidate the expression patterns of LGALS1 (galectin-1) and LGALS9 (galectin-9) genes in placental tissues of pregnancies affected by preterm prelabor rupture of membranes (PPROM). The overarching goal is to understand the potential roles of these galectins in the pathophysiology of PPROM, particularly in maternal-fetal immune tolerance and placental development. Material and methods: Conducted as a prospective, single-center study at the Gynecology and Obstetrics Clinical Hospital in Poznan, Poland, from June 2021 to May 2023, the research involved 25 participants, including 12 with PPROM and 13 healthy controls. Placental tissues were obtained, and RNA extraction was performed. Galectin gene expression (LGALS1 and LGALS9) was analyzed using quantitative real-time PCR. Demographic and clinical data were collected, and statistical analyses were employed to assess correlations between galectin expression and clinical parameters. Results: While significant differences were observed in gestational age at delivery and birth weight between the PPROM and control groups, the expression levels of LGALS1 and LGALS9 did not show statistically significant variations. Correlation analyses revealed no significant associations between galectin expression and various clinical parameters. Conclusions: Contrary to the hypothesis, this study did not identify significant alterations in galectin-1 and galectin-9 expression in placentas affected by PPROM. Despite the limitations of a small sample size, these findings provide initial insights into the potential roles of galectins in PPROM. Further research on larger cohorts is warranted to comprehensively understand the implications of galectin involvement in the pathophysiology of PPROM.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorBoron, Dorota G.
dc.contributor.authorMikołajczyk-Stecyna, Joanna
dc.contributor.authorChmurzyńska, Agata
dc.contributor.authorKurzawinska, Grazyna
dc.contributor.authorMarkwitz, Wieslaw
dc.contributor.authorSeremak-Mrozikiewicz, Agnieszka
dc.date.access2024-10-07
dc.date.accessioned2024-10-07T08:32:37Z
dc.date.available2024-10-07T08:32:37Z
dc.date.copyright2024-08-19
dc.date.issued2024
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0.00
dc.identifier.doi10.5603/gpl.98834
dc.identifier.eissn2543-6767
dc.identifier.issn0017-0011
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1778
dc.identifier.weblinkhttp://journals.viamedica.pl/ginekologia_polska/article/view/98834
dc.languageen
dc.relation.ispartofGinekologia Polska
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.subject.enPPROM
dc.subject.engalectins
dc.subject.enplacenta
dc.subtypeArticleEarlyAccess
dc.titleExpression of genes encoding galectin-1 and galectin-9 in placentas of pregnancies with preterm prelabor rupture of membranes
dc.typeJournalArticle
dspace.entity.typePublication