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Nieprawidłowości chromosomów płci jako istotne przyczyny zaburzeń rozwoju płci kotów

cris.virtual.author-orcid0000-0002-4238-0414
cris.virtual.author-orcid0000-0003-3485-1359
cris.virtual.author-orcid0000-0002-1041-3576
cris.virtual.author-orcid0000-0003-2539-9508
cris.virtualsource.author-orcid30dfea4c-e71f-4891-8e23-aafe00ca70e0
cris.virtualsource.author-orcidbc097627-d51d-4472-8ae6-8740c8dadfdf
cris.virtualsource.author-orcidb1f9951f-b018-4795-8cff-c7188dd69448
cris.virtualsource.author-orcid5b5c83e3-837f-42d1-855b-f39952dd433b
dc.abstract.enDisorders of sex development (DSDs) are defined as congenital conditionsin which a mismatch between chromosomal, gonadal and anatomic sex isobserved. DSDs are quite often reported in cats. Some DSD cases are diagnoseddue to unusual coat color in males (e.g. calico or tortoiseshell). These disorders affect reproduction, behavior and may lead to an increased risk of gonadal tumorigenesis. Three main categories of DSDs, based on sex chromosomes set, have been recognized: sex chromosome DSD, XX DSD and XY DSD. Cytogenetic analysis plays a crucial role in the classification of DSD cases. In this paper, an overview of sex chromosome DSD in cats is presented. Application of advanced cytogenetic analysis allowed to identify different abnormalities of sex chromosomes, including aneuploidies (X monosomy and XXY syndrome), structural rearrangements (X/Y translocation causing transfer of the SRY gene from Y to X chromosome or Y ring chromosome), and leukocyte XX/XY chimerism. It is recommended that cats with ambiguous genitalia should be subjected to cytogenetic diagnosis. Identification of genetic background of the observed sexual abnormalities facilitates distinguishing between hereditary (caused by gene mutations), and spontaneous sex chromosome abnormalities,which occurred during gametogenesis or embryonic development. In conclusion, a close collaboration between veterinary clinicians, cat breeders, and geneticists is highly recommended.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorSzczerbal, Izabela
dc.contributor.authorStachowiak, Monika
dc.contributor.authorNowacka-Woszuk, Joanna
dc.contributor.authorŚwitoński, Marek
dc.date.access2025-11-17
dc.date.accessioned2025-11-18T06:39:23Z
dc.date.available2025-11-18T06:39:23Z
dc.date.copyright2023-05
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.number5
dc.description.points100
dc.description.versionfinal_published
dc.description.volume98
dc.identifier.eissn1689-0299
dc.identifier.issn0137-6810
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5936
dc.identifier.weblinkhttp://zycie-weterynaryjne.pl/rocznik-98-rok-2023/
dc.languagepl
dc.language.otheren
dc.relation.ispartofŻycie Weterynaryjne
dc.relation.pages282-286
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enintersexuality
dc.subject.ensex chromosomes
dc.subject.enmonosomy
dc.subject.entrisomy
dc.subject.enmosaicism
dc.subject.enchimerism
dc.subject.entranslocation
dc.subject.enDSD
dc.subject.encats
dc.subtypeReviewArticle
dc.titleNieprawidłowości chromosomów płci jako istotne przyczyny zaburzeń rozwoju płci kotów
dc.title.alternativeSex chromosomes abnormalities are important causes of disorders of sex development in cats
dc.typeJournalArticle
dspace.entity.typePublication