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Neopterin Concentration in Umbilical Cord Blood as a Reflection of Maternal Insulin Resistance—A Pilot Study

cris.virtual.author-orcid0000-0002-7182-6905
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cris.virtual.author-orcid0000-0003-3179-503X
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cris.virtual.author-orcid0000-0003-0715-0223
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dc.abstract.enBackground/Objective: Insulin resistance (IR) during pregnancy, even in women with normal body mass index (BMI), may affect maternal and fetal metabolic and immune status. This study aimed to evaluate neopterin (NPT), leptin, insulin, and ghrelin concentrations in maternal blood (MB) and umbilical cord blood (CB) in normoglycemic women with and without IR, all with normal BMI. Methods: Peripheral and cord blood was collected from 36 Caucasian women with term, uncomplicated vaginal deliveries. The participants were classified into control (n = 16; age = 30.81 ± 4.875 years) and IR (n = 20; age = 31.95 ± 4.979 years) groups based on a professional medical diagnosis. Anthropometric parameters were recorded, and metabolic/hormonal markers were measured using ELISA and RIA. Results: NPT concentrations in CB were significantly higher in the IR group (p < 0.05), correlated positively with MB NPT levels (r = 0.3809, p < 0.05). A significantly higher concentration of both insulin and leptin was observed in the MB of women with IR compared to the control group (p < 0.0001), whereas in CB, only insulin concentration was significantly higher in the IR group than in healthy controls (p < 0.05). Ghrelin levels did not differ between the groups. Conclusions: Insulin resistance in non-obese pregnant women is associated with increased NPT concentration in CB, which may suggest fetal immune activation. However, defining the role of NTP as a metabolic “messenger” between mother and child requires further study.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.affiliation.instituteKatedra Hodowli Zwierząt i Oceny Surowców
dc.contributor.authorChęcińska-Kopeć, Aleksandra
dc.contributor.authorPruszyńska-Oszmałek, Ewa
dc.contributor.authorChecinska-Maciejewska, Zuzanna
dc.contributor.authorRekas-Dudziak, Anna
dc.contributor.authorWojciechowska, Małgorzata
dc.contributor.authorŚlósarz, Piotr Paweł
dc.contributor.authorKrauss, Hanna
dc.contributor.authorSzymanowski, Krzysztof
dc.contributor.authorKołodziejski, Paweł
dc.date.access2025-09-25
dc.date.accessioned2025-09-30T10:17:46Z
dc.date.available2025-09-30T10:17:46Z
dc.date.copyright2025-09-01
dc.date.issued2025
dc.description.abstract<jats:p>Background/Objective: Insulin resistance (IR) during pregnancy, even in women with normal body mass index (BMI), may affect maternal and fetal metabolic and immune status. This study aimed to evaluate neopterin (NPT), leptin, insulin, and ghrelin concentrations in maternal blood (MB) and umbilical cord blood (CB) in normoglycemic women with and without IR, all with normal BMI. Methods: Peripheral and cord blood was collected from 36 Caucasian women with term, uncomplicated vaginal deliveries. The participants were classified into control (n = 16; age = 30.81 ± 4.875 years) and IR (n = 20; age = 31.95 ± 4.979 years) groups based on a professional medical diagnosis. Anthropometric parameters were recorded, and metabolic/hormonal markers were measured using ELISA and RIA. Results: NPT concentrations in CB were significantly higher in the IR group (p &lt; 0.05), correlated positively with MB NPT levels (r = 0.3809, p &lt; 0.05). A significantly higher concentration of both insulin and leptin was observed in the MB of women with IR compared to the control group (p &lt; 0.0001), whereas in CB, only insulin concentration was significantly higher in the IR group than in healthy controls (p &lt; 0.05). Ghrelin levels did not differ between the groups. Conclusions: Insulin resistance in non-obese pregnant women is associated with increased NPT concentration in CB, which may suggest fetal immune activation. However, defining the role of NTP as a metabolic “messenger” between mother and child requires further study.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,5
dc.description.number9
dc.description.points100
dc.description.versionfinal_published
dc.description.volume14
dc.identifier.doi10.3390/biology14091157
dc.identifier.issn2079-7737
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5041
dc.identifier.weblinkhttps://www.mdpi.com/2079-7737/14/9/1157
dc.languageen
dc.relation.ispartofBiology
dc.relation.pagesart. 1157
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enneopterin
dc.subject.eninsulin resistance
dc.subject.enumbilical cord blood
dc.subject.enmaternal metabolism
dc.titleNeopterin Concentration in Umbilical Cord Blood as a Reflection of Maternal Insulin Resistance—A Pilot Study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue9
oaire.citation.volume14