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Interplay between vertebrate adaptive immunity and bacterial infectivity genes: Bank vole MHC versus Borrelia afzelii OspC

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dc.abstract.enCoevolution of parasites with their hosts may lead to balancing selection on genesinvolved in determining the specificity of host–parasite interactions, but examplesof such specific interactions in wild vertebrates are scarce. Here, we investigatedwhether the polymorphic outer surface protein C (OspC), used by the Lyme diseaseagent, Borrelia afzelii, to manipulate vertebrate host innate immunity, interacts withpolymorphic major histocompatibility genes (MHC), while concurrently eliciting astrong antibody response, in one of its main hosts in Europe, the bank vole. We foundsignals of balancing selection acting on OspC, resulting in little differentiation in OspCvariant frequencies between years. Neither MHC alleles nor their inferred functionalgroupings (supertypes) significantly predicted the specificity of infection with strainscarrying different OspC variants. However, we found that MHC alleles, but not super-types, significantly predicted the level of IgG antibodies against two common OspCvariants among seropositive individuals. Our results thus indicate that MHC allelesdiffer in their ability to induce antibody responses against specific OspC variants,which may contribute to selection of OspC polymorphism by the vole immune system.
dc.affiliationWydział Leśny i Technologii Drewna
dc.affiliation.instituteKatedra Entomologii i Fitopatologii Leśnej
dc.contributor.authorRóżańska‐Wróbel, Joanna
dc.contributor.authorMigalska, Magdalena
dc.contributor.authorUrbanowicz, Anna
dc.contributor.authorGrzybek, Maciej
dc.contributor.authorRego, Ryan O. M.
dc.contributor.authorBajer, Anna
dc.contributor.authorDwuznik‐Szarek, Dorota
dc.contributor.authorAlsarraf, Mohammed
dc.contributor.authorBehnke-Borowczyk, Jolanta
dc.contributor.authorBehnke, Jerzy M.
dc.contributor.authorRadwan, Jacek
dc.date.accessioned2024-11-06T08:13:49Z
dc.date.available2024-11-06T08:13:49Z
dc.date.issued2024
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>Coevolution of parasites with their hosts may lead to balancing selection on genes involved in determining the specificity of host–parasite interactions, but examples of such specific interactions in wild vertebrates are scarce. Here, we investigated whether the polymorphic outer surface protein C (OspC), used by the Lyme disease agent, <jats:italic>Borrelia afzelii</jats:italic>, to manipulate vertebrate host innate immunity, interacts with polymorphic major histocompatibility genes (MHC), while concurrently eliciting a strong antibody response, in one of its main hosts in Europe, the bank vole. We found signals of balancing selection acting on OspC, resulting in little differentiation in OspC variant frequencies between years. Neither MHC alleles nor their inferred functional groupings (supertypes) significantly predicted the specificity of infection with strains carrying different OspC variants. However, we found that MHC alleles, but not supertypes, significantly predicted the level of IgG antibodies against two common OspC variants among seropositive individuals. Our results thus indicate that MHC alleles differ in their ability to induce antibody responses against specific OspC variants, which may contribute to selection of OspC polymorphism by the vole immune system.</jats:p>
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0.00
dc.description.if4,5
dc.description.number21
dc.description.points140
dc.description.volume33
dc.identifier.doi10.1111/mec.17534
dc.identifier.eissn1365-294X
dc.identifier.issn0962-1083
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1992
dc.languageen
dc.relation.ispartofMolecular Ecology
dc.relation.pagesart. e17534
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enbacteria
dc.subject.enhost parasite interactions
dc.subject.enmammals
dc.subject.enpopulation genetics—empirical
dc.titleInterplay between vertebrate adaptive immunity and bacterial infectivity genes: Bank vole MHC versus Borrelia afzelii OspC
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue21
oaire.citation.volume33