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Structural Changes in Trabecular Bone, Cortical Bone and Hyaline Cartilage as Well as Disturbances in Bone Metabolism and Mineralization in an Animal Model of Secondary Osteoporosis in Clostridium perfringens Infection

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cris.virtual.author-orcid0000-0002-6606-7975
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cris.virtualsource.author-orcidf5683666-5139-4173-800e-278b2903d57b
dc.abstract.enThere is no information regarding whether changes in the microbiological balance of the gastrointestinal tract as a result of an infection with Clostridium perfringens influence the development of metabolic bone disorders. The experiment was carried out on male broiler chickens divided into two groups: control (n = 10) and experimental (n = 10). The experimental animals were infected with Clostridium perfringens between 17 and 20 days of age. The animals were euthanized at 42 days of age. The structural parameters of the trabecular bone, cortical bone, and hyaline cartilage as well as the mineralization of the bone were determined. The metabolism of the skeletal system was assessed by determining the levels of bone turnover markers, hormones, and minerals in the blood serum. The results confirm that the disturbed composition of the gastrointestinal microflora has an impact on the mineralization and metabolism of bone tissue, leading to the structural changes in cortical bone, trabecular bone, and hyaline cartilage. On the basis of the obtained results, it can be concluded that changes in the microenvironment of the gastrointestinal tract by infection with C. perfringens may have an impact on the earlier development of osteoporosis.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Żywienia Zwierząt
dc.contributor.authorTomczyk-Warunek, Agnieszka
dc.contributor.authorBlicharski, Tomasz
dc.contributor.authorMuszyński, Siemowit
dc.contributor.authorTomaszewska, Ewa
dc.contributor.authorDobrowolski, Piotr
dc.contributor.authorBlicharski, Rudolf
dc.contributor.authorJarecki, Jaromir
dc.contributor.authorArczewska-Włosek, Anna
dc.contributor.authorŚwiątkiewicz, Sylwester
dc.contributor.authorJózefiak, Damian
dc.date.access2026-02-27
dc.date.accessioned2026-03-05T09:09:14Z
dc.date.available2026-03-05T09:09:14Z
dc.date.copyright2021-12-30
dc.date.issued2022
dc.description.abstract<jats:p>There is no information regarding whether changes in the microbiological balance of the gastrointestinal tract as a result of an infection with Clostridium perfringens influence the development of metabolic bone disorders. The experiment was carried out on male broiler chickens divided into two groups: control (n = 10) and experimental (n = 10). The experimental animals were infected with Clostridium perfringens between 17 and 20 days of age. The animals were euthanized at 42 days of age. The structural parameters of the trabecular bone, cortical bone, and hyaline cartilage as well as the mineralization of the bone were determined. The metabolism of the skeletal system was assessed by determining the levels of bone turnover markers, hormones, and minerals in the blood serum. The results confirm that the disturbed composition of the gastrointestinal microflora has an impact on the mineralization and metabolism of bone tissue, leading to the structural changes in cortical bone, trabecular bone, and hyaline cartilage. On the basis of the obtained results, it can be concluded that changes in the microenvironment of the gastrointestinal tract by infection with C. perfringens may have an impact on the earlier development of osteoporosis.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,9
dc.description.number1
dc.description.points140
dc.description.versionfinal_published
dc.description.volume11
dc.identifier.doi10.3390/jcm11010205
dc.identifier.issn2077-0383
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7621
dc.identifier.weblinkhttps://www.mdpi.com/2077-0383/11/1/205
dc.languageen
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.pagesart. 205
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enosteoporosis
dc.subject.enmetabolic bone disorders
dc.subject.enClostridium perfringens
dc.subject.engastrointestinal
dc.subject.enmicroflora
dc.subject.enshort-term infection
dc.titleStructural Changes in Trabecular Bone, Cortical Bone and Hyaline Cartilage as Well as Disturbances in Bone Metabolism and Mineralization in an Animal Model of Secondary Osteoporosis in Clostridium perfringens Infection
dc.title.volumeSpecial Issue Secondary Osteoporosis and Metabolic Bone Diseases
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume11