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A Preliminary Study Investigating the Effects of Elevated Antioxidant Capacity of Daily Snacks on the Body’s Antioxidant Defences in Patients with CVD

cris.virtual.author-orcid0000-0002-6085-4855
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid20258df6-7058-4f33-9a7a-ab392117b6f3
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enThe antioxidant potential of foods plays a vital role in counteracting oxidative stress and its consequences in the body. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are the primary line of defence against cellular damage caused by reactive oxygen species (ROS). Glutathione is considered to be the most vital antioxidant for the body because its changes during oxidative stress increase the risk of CVD. The dietary antioxidant capacity supporting the glutathione defence system is not known. Therefore, we analysed the glutathione defence-related markers changes in the serum of CVD patients under the dietary supplementation of increased antioxidant capacity snacks. Patients were split into groups according to inclusion criteria and dietary intervention (DI) design. The serum concentration of GPx and GST (glutathione-S-transferase) was measured before and after the 6-week DI. During the DI, CVD and control (CON) subjects increased the total diet antioxidant capacity by 48% and 21%, respectively. It resulted in a significantly decreased GST (from 3.71 to 2.54 U/g Hb, p < 0.05) and an increased GPx (from 33.90 to 38.3 U/L). The results in the CON group did not reveal significant changes in GST and GPx. This study demonstrated that an increased antioxidant capacity might be associated with improving glutathione-related defence. However, the conclusion is not substantial due to the small sample used in this study.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorCzłapka-Matyasik, Magdalena
dc.contributor.authorGut, Pawel
dc.date.access2025-06-04
dc.date.accessioned2025-09-04T12:00:18Z
dc.date.available2025-09-04T12:00:18Z
dc.date.copyright2023-05-10
dc.date.issued2023
dc.description.abstract<jats:p>The antioxidant potential of foods plays a vital role in counteracting oxidative stress and its consequences in the body. Superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) are the primary line of defence against cellular damage caused by reactive oxygen species (ROS). Glutathione is considered to be the most vital antioxidant for the body because its changes during oxidative stress increase the risk of CVD. The dietary antioxidant capacity supporting the glutathione defence system is not known. Therefore, we analysed the glutathione defence-related markers changes in the serum of CVD patients under the dietary supplementation of increased antioxidant capacity snacks. Patients were split into groups according to inclusion criteria and dietary intervention (DI) design. The serum concentration of GPx and GST (glutathione-S-transferase) was measured before and after the 6-week DI. During the DI, CVD and control (CON) subjects increased the total diet antioxidant capacity by 48% and 21%, respectively. It resulted in a significantly decreased GST (from 3.71 to 2.54 U/g Hb, p &lt; 0.05) and an increased GPx (from 33.90 to 38.3 U/L). The results in the CON group did not reveal significant changes in GST and GPx. This study demonstrated that an increased antioxidant capacity might be associated with improving glutathione-related defence. However, the conclusion is not substantial due to the small sample used in this study.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,5
dc.description.number10
dc.description.points100
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3390/app13105863
dc.identifier.issn2076-3417
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4642
dc.identifier.weblinkhttp://www.mdpi.com/2076-3417/13/10/5863
dc.languageen
dc.relation.ispartofApplied Sciences (Switzerland)
dc.relation.pagesart. 5863
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enantioxidants
dc.subject.englutathione peroxidase
dc.subject.englutathione-S-transferase
dc.subject.endietary intervention
dc.subject.encardiovascular disease
dc.subject.enantioxidant capacity
dc.subject.enORAC
dc.titleA Preliminary Study Investigating the Effects of Elevated Antioxidant Capacity of Daily Snacks on the Body’s Antioxidant Defences in Patients with CVD
dc.title.volumeSpecial Issue Chemical and Functional Properties of Food and Natural Products
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume13