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Plant homocysteine, a methionine precursor and plant’s hallmark of metabolic disorders

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cris.virtual.author-orcid0000-0003-2281-223X
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cris.virtualsource.author-orcid4e2dc392-8cf9-4b89-a596-333bcc45d7cd
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dc.abstract.enHomocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid, which arises from redox-sensitive methionine metabolism. In plants, Hcy synthesis involves both cystathionine β-lyase and S-adenosylhomocysteine hydrolase activities. Thus, Hcy itself is crucial for de novo methionine synthesis and S-adenosylmethionine recycling, influencing the formation of ethylene, polyamines, and nicotianamine. Research on mammalian cells has shown biotoxicity of this amino acid, as Hcy accumulation triggers oxidative stress and the associated lipid peroxidation process. In addition, the presence of highly reactive groups induces Hcy and Hcy derivatives to modify proteins by changing their structure and function. Currently, Hcy is recognized as a critical, independent hallmark of many degenerative metabolic diseases. Research results indicate that an enhanced Hcy level is also toxic to yeast and bacteria cells. In contrast, in the case of plants the metabolic status of Hcy remains poorly examined and understood. However, the presence of the toxic Hcy metabolites and Hcy over-accumulation during the development of an infectious disease seem to suggest harmful effects of this amino acid also in plant cells. The review highlights potential implications of Hcy metabolism in plant physiological disorders caused by environmental stresses. Moreover, recent research advances emphasize that recognizing the Hcy mode of action in various plant systems facilitates verification of the potential status of Hcy metabolites as bioindicators of metabolism disorders and thus may constitute an element of broadly understood biomonitoring.
dc.affiliationWydział Rolnictwa, Ogrodnictwa i Bioinżynierii
dc.affiliation.instituteKatedra Fizjologii Roślin
dc.contributor.authorSobieszczuk-Nowicka, Ewa
dc.contributor.authorArasimowicz-Jelonek, Magdalena
dc.contributor.authorTanwar, Umesh Kumar
dc.contributor.authorFloryszak-Wieczorek, Jolanta
dc.date.access2025-10-28
dc.date.accessioned2025-10-28T12:46:19Z
dc.date.available2025-10-28T12:46:19Z
dc.date.copyright2022-12-08
dc.date.issued2022
dc.description.abstract<jats:p>Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid, which arises from redox-sensitive methionine metabolism. In plants, Hcy synthesis involves both cystathionine β-lyase and <jats:italic>S</jats:italic>-adenosylhomocysteine hydrolase activities. Thus, Hcy itself is crucial for <jats:italic>de novo</jats:italic> methionine synthesis and <jats:italic>S</jats:italic>-adenosylmethionine recycling, influencing the formation of ethylene, polyamines, and nicotianamine. Research on mammalian cells has shown biotoxicity of this amino acid, as Hcy accumulation triggers oxidative stress and the associated lipid peroxidation process. In addition, the presence of highly reactive groups induces Hcy and Hcy derivatives to modify proteins by changing their structure and function. Currently, Hcy is recognized as a critical, independent hallmark of many degenerative metabolic diseases. Research results indicate that an enhanced Hcy level is also toxic to yeast and bacteria cells. In contrast, in the case of plants the metabolic status of Hcy remains poorly examined and understood. However, the presence of the toxic Hcy metabolites and Hcy over-accumulation during the development of an infectious disease seem to suggest harmful effects of this amino acid also in plant cells. The review highlights potential implications of Hcy metabolism in plant physiological disorders caused by environmental stresses. Moreover, recent research advances emphasize that recognizing the Hcy mode of action in various plant systems facilitates verification of the potential status of Hcy metabolites as bioindicators of metabolism disorders and thus may constitute an element of broadly understood biomonitoring.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_act
dc.description.financecost8984,31
dc.description.if5,6
dc.description.points100
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3389/fpls.2022.1044944
dc.identifier.issn1664-462X
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5552
dc.identifier.weblinkhttps://www.frontiersin.org/journals/plant-science/articles/10.3389/fpls.2022.1044944/full
dc.languageen
dc.relation.ispartofFrontiers in Plant Science
dc.relation.pagesart. 1044944
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enhomocysteine
dc.subject.ennon-proteinogenic amino acid
dc.subject.enhomocysteine derivatives
dc.subject.enmethionine metabolism
dc.subject.enstress biomarker
dc.titlePlant homocysteine, a methionine precursor and plant’s hallmark of metabolic disorders
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume13