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A Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide

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cris.virtual.author-orcid0000-0002-0120-2734
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cris.virtualsource.author-orcid44370511-a743-43d2-9522-1c489f4cabcf
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dc.abstract.enFisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide (scCO2). Characterisation, including powder X-ray diffraction and Fourier-transform infrared spectroscopy, confirmed amorphization and assessed intermolecular interactions. The amorphous FIS dispersion exhibited enhanced solubility, dissolution profiles, and bioavailability compared to the crystalline form. In vitro, the amorphous FIS dispersion demonstrated antioxidant activity (the ABTS, CUPRAC, DDPH, FRAP assays) and neuroprotective effects by inhibiting acetylcholinesterase and butyrylcholinesterase. FIS modulated gut microbiota, reducing potentially pathogenic gram-negative bacteria without affecting probiotic microflora. These improvements in solubility, antioxidant and neuroprotective activities, and gut microbiome modulation suggest the potential for optimising FIS delivery systems to leverage its health-promoting properties while addressing oral functionality limitations.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSip, Szymon
dc.contributor.authorRosiak, Natalia
dc.contributor.authorSip, Anna
dc.contributor.authorŻarowski, Marcin
dc.contributor.authorHojan, Katarzyna
dc.contributor.authorCielecka-Piontek, Judyta
dc.date.access2025-08-07
dc.date.accessioned2025-08-28T09:35:17Z
dc.date.available2025-08-28T09:35:17Z
dc.date.copyright2023-12-21
dc.date.issued2024
dc.description.abstract<jats:p>Fisetin (FIS), a senolytic flavonoid, mitigates age-related neuroprotective changes. An amorphous FIS dispersion with a co-carrier was prepared using supercritical fluid extraction with carbon dioxide (scCO2). Characterisation, including powder X-ray diffraction and Fourier-transform infrared spectroscopy, confirmed amorphization and assessed intermolecular interactions. The amorphous FIS dispersion exhibited enhanced solubility, dissolution profiles, and bioavailability compared to the crystalline form. In vitro, the amorphous FIS dispersion demonstrated antioxidant activity (the ABTS, CUPRAC, DDPH, FRAP assays) and neuroprotective effects by inhibiting acetylcholinesterase and butyrylcholinesterase. FIS modulated gut microbiota, reducing potentially pathogenic gram-negative bacteria without affecting probiotic microflora. These improvements in solubility, antioxidant and neuroprotective activities, and gut microbiome modulation suggest the potential for optimising FIS delivery systems to leverage its health-promoting properties while addressing oral functionality limitations.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if6,6
dc.description.number1
dc.description.points100
dc.description.versionfinal_published
dc.description.volume13
dc.identifier.doi10.3390/antiox13010024
dc.identifier.issn2076-3921
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4467
dc.identifier.weblinkhttps://www.mdpi.com/2076-3921/13/1/24
dc.languageen
dc.relation.ispartofAntioxidants
dc.relation.pagesart. 24
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enfisetin
dc.subject.enamorphous
dc.subject.ensupercritical CO2
dc.subject.ensolubility
dc.subject.enmicrobiome
dc.subject.enneuroprotection
dc.titleA Fisetin Delivery System for Neuroprotection: A Co-Amorphous Dispersion Prepared in Supercritical Carbon Dioxide
dc.title.volumeSpecial Issue New Strategies for the Use of Antioxidants in Neuroprotection and Neurorecovery
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume13