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Star Polymers as a Reducing Agent of Silver Salt and a Carrier for Silver Nanoparticles

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dc.abstract.enStar polymers-macromolecules featuring multiple arms radiating from a central core—offer unique potential for biomedical applications due to their tunable architecture, multifunctionality and ability to incorporate stimuli-responsive and biocompatible components. In this study, functional star polymers with oligo (ethylene glycol) methyl ether methacrylate (OEOMA) arms and 2-(dimethylamino)ethyl methacrylate (DMAEMA) core units were synthesized via atom transfer radical polymerization (ATRP) using the “arm-first” strategy. The star polymers were used as nanoreactors for the in situ reduction of silver nitrate to form silver nanoparticles (AgNPs) without additional reducing agents. UV–Vis spectroscopy confirmed the formation of spherical AgNPs with absorption maxima around 430 nm, and transmission electron microscopy revealed uniform particle morphology. These hybrid nanomaterials (STR-AgNPs) were incorporated into polymethyl methacrylate (PMMA)-based bone cement to impart antibacterial properties. Mechanical testing showed that the compressive strength remained within acceptable limits, while antibacterial assays against E. coli demonstrated a significant inhibition of bacterial growth. These findings suggest that STR-AgNPs serve as promising candidates for infection-resistant bone implants, providing localized antibacterial effects while maintaining mechanical integrity and biocompatibility.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Fizyki i Biofizyki
dc.contributor.authorSzcześniak, Katarzyna
dc.contributor.authorPrzesławski, Grzegorz
dc.contributor.authorKotecki, Jakub
dc.contributor.authorAndrzejewska, Weronika
dc.contributor.authorFiedorowicz, Katarzyna
dc.contributor.authorWoźniak-Budych, Marta
dc.contributor.authorJarzębski, Maciej
dc.contributor.authorGajewski, Piotr [PP]
dc.contributor.authorMarcinkowska, Agnieszka
dc.date.access2025-11-24
dc.date.accessioned2025-11-24T13:44:37Z
dc.date.available2025-11-24T13:44:37Z
dc.date.copyright2025-06-25
dc.date.issued2025
dc.description.abstract<jats:p>Star polymers—macromolecules featuring multiple arms radiating from a central core—offer unique potential for biomedical applications due to their tunable architecture, multifunctionality and ability to incorporate stimuli-responsive and biocompatible components. In this study, functional star polymers with oligo (ethylene glycol) methyl ether methacrylate (OEOMA) arms and 2-(dimethylamino)ethyl methacrylate (DMAEMA) core units were synthesized via atom transfer radical polymerization (ATRP) using the “arm-first” strategy. The star polymers were used as nanoreactors for the in situ reduction of silver nitrate to form silver nanoparticles (AgNPs) without additional reducing agents. UV–Vis spectroscopy confirmed the formation of spherical AgNPs with absorption maxima around 430 nm, and transmission electron microscopy revealed uniform particle morphology. These hybrid nanomaterials (STR-AgNPs) were incorporated into polymethyl methacrylate (PMMA)-based bone cement to impart antibacterial properties. Mechanical testing showed that the compressive strength remained within acceptable limits, while antibacterial assays against E. coli demonstrated a significant inhibition of bacterial growth. These findings suggest that STR-AgNPs serve as promising candidates for infection-resistant bone implants, providing localized antibacterial effects while maintaining mechanical integrity and biocompatibility.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,2
dc.description.number13
dc.description.points140
dc.description.versionfinal_published
dc.description.volume18
dc.identifier.doi10.3390/ma18133009
dc.identifier.issn1996-1944
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6085
dc.identifier.weblinkhttps://www.mdpi.com/1996-1944/18/13/3009
dc.languageen
dc.relation.ispartofMaterials
dc.relation.pagesart. 3009
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enstar polymers
dc.subject.ensilver nanoparticles
dc.subject.enbone cements
dc.subject.enantibacterial activity
dc.titleStar Polymers as a Reducing Agent of Silver Salt and a Carrier for Silver Nanoparticles
dc.title.volumeSpecial Issue Multi-Scale Bionic Materials: Interfacial Design, Effective Fabrication and Functional Application
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue13
oaire.citation.volume18