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Methylglyoxal impairs β-adrenergic signalling in primary rat adipocytes

cris.virtual.author-orcid0000-0002-9067-6682
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0002-6828-0534
cris.virtualsource.author-orcidff566057-8099-4bac-bd4c-896c46beaa7c
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orciddaf06652-dcef-4aa8-b66a-bdb14028e85d
dc.abstract.enMethylglyoxal (MG) is dicarbonyl aldehyde generated intracellularly from glucose and from some other compounds. Its increased formation is associated with several harmful consequences. In the present study, short-term effects of MG on metabolism of isolated rat adipocytes were determined. Insulin-induced lipogenesis was unchanged by MG. However, epinephrine-stimulated lipolysis was shown to be significantly reduced in adipocytes exposed to 200 µM MG. This inhibitory effect was similar in the presence of low and high concentrations of glucose, and also in the presence of alanine. However, MG failed to affect lipolysis induced by forskolin (activator of adenylate cyclase), dibutyryl-cAMP (activator of PKA) and DPCPX (adenosine A1 receptor antagonist). It was also revealed that lipolysis was unchanged by MG in fat cells pre-incubated with this compound, and then stimulated with epinephrine alone. Our results suggest that MG may impair β-adrenergic signalling in rat adipocytes due to interaction with epinephrine, and thereby disturbs lipolysis.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.contributor.authorSzkudelski, Tomasz
dc.contributor.authorCieślewicz, Aleksandra
dc.contributor.authorSzkudelska, Katarzyna
dc.date.accessioned2026-02-09T07:47:39Z
dc.date.available2026-02-09T07:47:39Z
dc.date.issued2022
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,0
dc.description.number2
dc.description.points70
dc.description.volume128
dc.identifier.doi10.1080/13813455.2019.1684953
dc.identifier.eissn1744-4160
dc.identifier.issn1381-3455
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7238
dc.languageen
dc.relation.ispartofArchives of Physiology and Biochemistry
dc.relation.pages394-401
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enadipocyty
dc.subject.enmetyloglioksal
dc.subject.enmetabolizm
dc.titleMethylglyoxal impairs β-adrenergic signalling in primary rat adipocytes
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume128