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Stilbene-based strategies for the management of endometriosis: targeting cell adhesion, migration, and ECM-driven invasion

cris.virtual.author-orcid0000-0003-2725-0467
cris.virtual.author-orcid0000-0002-4385-0051
cris.virtualsource.author-orcidd077b699-93dd-4a9f-804f-4c575429c392
cris.virtualsource.author-orcid48ec8e95-930e-4be2-b47a-b597e5d7440b
dc.abstract.enEndometriosis develops when endometrial fragments implant in the peritoneal cavity, overcome structural barriers, or enter through existing tissue injury, leading to the formation of ectopic endometrium-like tissue. This study aimed to investigate the therapeutic potential of resveratrol and its natural analogs in modulating migratory, invasive, and adhesive interactions of endometriotic cells. Adhesion to ECM components, such as collagen I and fibronectin, was assessed by crystal violet staining and showed that stilbenes reduced cell attachment more pronouncedly on fibronectin-coated surfaces. Migration and invasion through Matrigel-coated chambers were dose-dependently suppressed by all compounds, with pterostilbene and piceatannol exerting the most potent inhibitory effects. Expression and secretion of key ECM proteolysis mediators, MMP-2 and TIMP-2, analyzed by qRT-PCR and ELISA, were modulated by stilbene treatment. These findings highlight the potential of resveratrol and its analogs as promising agents for preventing local growth, migration, and invasion of endometriotic cells.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorGołąbek-Grenda, Agata
dc.contributor.authorOlejnik, Anna
dc.date.access2026-04-15
dc.date.accessioned2026-04-17T10:27:42Z
dc.date.available2026-04-17T10:27:42Z
dc.date.copyright2026-04-03
dc.date.issued2026
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,0
dc.description.numberMay 2026
dc.description.points100
dc.description.versionfinal_published
dc.description.volume140
dc.identifier.doi10.1016/j.jff.2026.107277
dc.identifier.eissn2214-9414
dc.identifier.issn1756-4646
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/8108
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S1756464626001271
dc.languageen
dc.relation.ispartofJournal of Functional Foods
dc.relation.pagesart. 107277
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enstilbenes
dc.subject.enresveratrol analogs
dc.subject.enendometriosis
dc.subject.en12Z endometriotic cells
dc.subject.enECM proteolysis
dc.subject.enmetalloproteinases
dc.titleStilbene-based strategies for the management of endometriosis: targeting cell adhesion, migration, and ECM-driven invasion
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume140