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Serum bile acids in cystic fibrosis patients – glycodeoxycholic acid as a potential marker of liver disease

cris.virtual.author-orcid0000-0003-1282-7446
cris.virtual.author-orcid0000-0003-4570-7221
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cris.virtualsource.author-orcidd08fea3d-c0ab-4b69-8ef3-d5c4dc26a46c
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dc.abstract.enBackground Cystic fibrosis (CF) and CF-related liver disease can lead to disturbances in bile acid metabolism. Aim This study determined serum bile acid concentrations in CF to define their usefulness in liver disease assessment. Methods Primary, secondary and conjugated bile acid levels were measured in three CF groups (25 patients each) exhibiting: liver cirrhosis, other liver disease, no liver disease, and in 25 healthy subjects (HS). Results Bile acid levels were higher in CF patients than in HS, except for glycodeoxycholic acid (GDCA). However, bile acid concentrations did not differ between patients with cirrhosis and other liver involvement. GDCA and deoxycholic acid (DCA) differentiated CF patients with non-cirrhotic liver disease from those without liver disease (GDCA-AUC: 0.924, 95%CI 0.822–1.000, p<0.001; DCA-AUC: 0.867, 95%CI: 0.731–1.000, p<0.001). Principal component analysis revealed that in CF liver disease was related to GDCA, GGTP activity, severe genotype and pancreatic insufficiency. Conclusions A CF-specific bile acid profile was defined and shown to relate to liver disease. GDCA differentiates patients with non-cirrhotic liver involvement from those with no detectable liver disease. Hence, GDCA is a candidate for validation as a biomarker of non-cirrhotic progression of liver disease in CF.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Technologii Żywności Pochodzenia Roślinnego
dc.contributor.authorDrzymała-Czyż, Sławomira
dc.contributor.authorDziedzic, Krzysztof
dc.contributor.authorSzwengiel, Artur
dc.contributor.authorKrzyżanowska-Jankowska, Patrycja
dc.contributor.authorNowak, Jan K.
dc.contributor.authorNowicka, Agata
dc.contributor.authorAringazina, Raisa
dc.contributor.authorDrzymała, Sylwia
dc.contributor.authorKashirskaya, Nataliya
dc.contributor.authorWalkowiak, Jarosław
dc.date.accessioned2026-01-07T07:19:33Z
dc.date.available2026-01-07T07:19:33Z
dc.date.issued2022
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,5
dc.description.number1
dc.description.points100
dc.description.volume54
dc.identifier.doi10.1016/j.dld.2021.06.034
dc.identifier.eissn1878-3562
dc.identifier.issn1590-8658
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6602
dc.languageen
dc.relation.ispartofDigestive and Liver Disease
dc.relation.pages111-117
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.encholic acid
dc.subject.encystic fibrosis liver disease
dc.subject.endeoxycholic acid
dc.subject.enliver cirrhosis
dc.titleSerum bile acids in cystic fibrosis patients – glycodeoxycholic acid as a potential marker of liver disease
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume54