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Modulating effects of steviol and steviol glycosides on adipogenesis, lipogenesis, glucose uptake and insulin resistance in 3T3-L1 adipocyte model

cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid0000-0001-7706-4035
cris.virtual.author-orcid0000-0002-4399-7459
cris.virtual.author-orcid0000-0002-4385-0051
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid349c35ce-c6ee-4d8a-9a7f-b3aace65dbd7
cris.virtualsource.author-orcid10fdded3-5140-4fbe-80bb-03575e77544c
cris.virtualsource.author-orcid48ec8e95-930e-4be2-b47a-b597e5d7440b
dc.abstract.enStevia rebaudiana Bertoni is famous for sweetness due to the content of steviol glycosides (SG). This study aimed to determine the effect of SG (stevioside, rebaudioside A) and steviol on adipogenesis and lipogenesis in the 3T3-L1 model. Test compounds were also analysed for their ability to affect glucose uptake in hypertrophied insulin-resistant 3T3-L1 adipocytes. The most active compound in modulating adipogenesis, lipogenesis and insulin resistance was steviol, SG metabolism product. Steviol (10 μM, 100 μM) significantly down-regulated the expression of adipogenic transcription factors (PPARγ, C/EBPα, SREBP1) and lipogenic genes (FAS, aP2, LPL), which caused decreased lipid accumulation and triglyceride content in adipocytes. Treatment of insulin-resistant adipocytes with steviol (1 μM) and stevioside (1 μM, 10 μM) increased GLUT-4 transcript level and improved glucose uptake. Steviol also lowered resistin gene expression, which may mitigate insulin resistance in hypertrophied adipocytes. This study promotes SG as potential health-promoting ingredients in low-calorie functional foods.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorKurek, Jakub Michał
dc.contributor.authorZielińska-Wasielica, Joanna
dc.contributor.authorKowalska, Katarzyna
dc.contributor.authorKrejpcio, Zbigniew
dc.contributor.authorOlejnik, Anna
dc.date.access2026-03-09
dc.date.accessioned2026-03-09T08:09:34Z
dc.date.available2026-03-09T08:09:34Z
dc.date.copyright2022-06-06
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,6
dc.description.numberJuly 2022
dc.description.points100
dc.description.versionfinal_published
dc.description.volume94
dc.identifier.doi10.1016/j.jff.2022.105141
dc.identifier.eissn2214-9414
dc.identifier.issn1756-4646
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7711
dc.identifier.weblinkhttp://www.sciencedirect.com/science/article/pii/S1756464622002110
dc.languageen
dc.relation.ispartofJournal of Functional Foods
dc.relation.pagesart. 105141
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enstevia
dc.subject.enstevioside
dc.subject.enrebaudioside A
dc.subject.ensteviol
dc.subject.enadipogenesis
dc.subject.enlipogenesis
dc.subject.eninsulin-resistance
dc.subject.enhypertrophic adipocytes
dc.titleModulating effects of steviol and steviol glycosides on adipogenesis, lipogenesis, glucose uptake and insulin resistance in 3T3-L1 adipocyte model
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume94