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The role of the orexin (hypocretin) system in controlling energy homeostasis, endocrine system, and reproduction in pigs and other living organisms

cris.virtual.author-orcid0000-0002-3651-0972
cris.virtual.author-orcid0000-0002-4563-3798
cris.virtual.author-orcid0000-0003-4961-2959
cris.virtual.author-orcid0000-0002-1948-6544
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cris.virtual.author-orcid0000-0003-4059-1362
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cris.virtualsource.author-orcid652e209d-434a-47b3-b5fb-64c0aac5a84c
cris.virtualsource.author-orcid2887b0c9-4f57-4235-a68f-057f9a3211f9
cris.virtualsource.author-orcidd262a047-0e71-4e00-b46b-5167dd661a3d
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cris.virtualsource.author-orcidb5ca3f7e-8c5b-47d7-b9c2-582f5ffa0e29
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cris.virtualsource.author-orcid9118c61a-b066-4efc-a7af-486f9ebf9021
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dc.abstract.enOrexins A (OXA) and B (OXB) (hypocretin 1 and 2) are neuropeptides produced in the brain and peripheral tissues. Biological activities of orexins are mediated through activation of two G-protein coupled receptors termed as orexin 1 receptor (OX1R) and orexin 2 receptor (OX1R). Orexin system (OXA, OXB, OX1R, OX2R) was implicated in controlling sleep, energy expenditure, appetite, reproduction as well as metabolism and energy homeostasis. In this review, we summarize the current knowledge regarding the role of the orexin system in controlling porcine physiology. Particularly, we review and discuss evidence indicating that in pig and other living organisms, orexins and their receptors modulate the energy homeostasis, reproduction as well as functions of peripheral tissues including the pancreas, adrenal glands, gastro-intestinal tract and adipose tissue.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.contributor.authorWojciechowicz, Tatiana
dc.contributor.authorRybska, Marta
dc.contributor.authorSmolinska, N.
dc.contributor.authorKaminski, T.
dc.contributor.authorRak, A.
dc.contributor.authorWłodarek, Jan
dc.contributor.authorNowak, Krzysztof W.
dc.contributor.authorSkrzypski, Marek
dc.date.access2025-07-04
dc.date.accessioned2025-10-27T11:27:09Z
dc.date.available2025-10-27T11:27:09Z
dc.date.copyright2023-12-31
dc.date.issued2023
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,0
dc.description.number6
dc.description.points100
dc.description.versionfinal_published
dc.description.volume74
dc.identifier.doi10.26402/jpp.2023.6.01
dc.identifier.issn0867-5910
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5477
dc.identifier.weblinkhttps://www.jpp.krakow.pl/
dc.languageen
dc.relation.ispartofJournal of Physiology and Pharmacology
dc.relation.pages603-614
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enorexin
dc.subject.enhypocretin
dc.subject.enmetabolism
dc.subject.enpig
dc.subject.enreproduction
dc.subject.enendocrine system
dc.subject.enadipose tissue
dc.subject.enadrenal glands
dc.subject.enhypothalamus
dc.subject.enpituitary
dc.subtypeReviewArticle
dc.titleThe role of the orexin (hypocretin) system in controlling energy homeostasis, endocrine system, and reproduction in pigs and other living organisms
dc.typeJournalArticle
dspace.entity.typePublication