Simple item page
 

The relevance of the heme oxygenase system in alleviating diabetes-related hormonal and metabolic disorders

cris.lastimport.scopus2025-10-23T06:56:06Z
cris.virtual.author-orcid0000-0002-9067-6682
cris.virtual.author-orcid0000-0002-6828-0534
cris.virtualsource.author-orcidff566057-8099-4bac-bd4c-896c46beaa7c
cris.virtualsource.author-orciddaf06652-dcef-4aa8-b66a-bdb14028e85d
dc.abstract.enHeme oxygenase (HO) is an enzyme that catalyzes heme degradation. HO dysfunction is linked to various pathological conditions, including diabetes. Results of animal studies indicate that HO expression and activity are downregulated in experimentally induced diabetes. This is associated with severe hormonal and metabolic disturbances. However, these pathological changes have been shown to be reversed by therapy with HO activators. In animals with experimentally induced diabetes, HO was upregulated by genetic manipulation or by pharmacological activators such as hemin and cobalt protoporphyrin. Induction of HO alleviated elevated blood glucose levels and improved insulin action, among other effects. This effect resulted from beneficial changes in the main insulin-sensitive tissues, i.e., the skeletal muscle, the liver, and the adipose tissue. The action of HO activators was due to positive alterations in pivotal signaling molecules and regulatory enzymes. Furthermore, diabetes-related oxidative and inflammatory stress was reduced due to HO induction. HO upregulation was effective in various animal models of type 1 and type 2 diabetes. These data suggest the possibility of testing HO activators as a potential tool for alleviating hormonal and metabolic disorders in people with diabetes.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury ZwierzÄ…t
dc.contributor.authorSzkudelski, Tomasz
dc.contributor.authorSzkudelska, Katarzyna
dc.date.access2025-03-20
dc.date.accessioned2025-03-20T10:25:11Z
dc.date.available2025-03-20T10:25:11Z
dc.date.copyright2024-10-25
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_research
dc.description.financecost18575,24
dc.description.if4,2
dc.description.number1
dc.description.points140
dc.description.versionfinal_published
dc.description.volume1871
dc.identifier.doi10.1016/j.bbadis.2024.167552
dc.identifier.eissn1879-260X
dc.identifier.issn0925-4439
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2615
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0925443924005465
dc.languageen
dc.relation.ispartofBiochimica et Biophysica Acta - Molecular Basis of Disease
dc.relation.pagesart. 167552
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOTHER
dc.subject.enexperimental diabetes
dc.subject.enhormones
dc.subject.enheme oxygenase
dc.subject.enrodents
dc.titleThe relevance of the heme oxygenase system in alleviating diabetes-related hormonal and metabolic disorders
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume1871