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Effect of obesity and hypothyroidism on hepcidin concentration in pregnancy - a pilot study using maternal and umbilical cord blood at delivery day

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cris.virtual.author-orcid0000-0001-9792-1145
cris.virtual.author-orcid0000-0002-0081-7585
cris.virtual.author-orcid0000-0003-0715-0223
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cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enHepcidin is a primary regulator of iron metabolism in the human body. By promoting ferroportin degradation, hepcidin reduces intestinal iron absorption and its release from intracellular stores. In the course of pregnancy, gradually declining hepcidin concentrations encourage placental iron transfer, thereby providing the appropriate amount of iron for fetal development. Hence, we aimed to investigate changes in maternal and cord blood hepcidin and iron metabolism parameters in normal-weight (n=17) and obese (n=17) gestating women, as well as gravid women with a history of hypothyroidism following the restoration of euthyroidism (n=17). All blood samples were taken on the day of delivery, and ELISA kits were used for measurements. A significant increase in maternal hepcidin concentration was observed in obese pregnant women, compared to normal-weight controls (29.53±4.20 ng/mL vs. 25.69±5.70 ng/mL; P<0.05). However, only a slight, insignificant tendency for lower hepcidin was noted in the hypothyroid group, compared to the healthy controls (23.10±6.00 ng/mL vs. 25.69±5.70 ng/mL; P=NS). Moreover, decreased maternal free triiodothyronine, triiodothyronine, free thyroxine, and ferritin levels were revealed in the hypothyroid group, compared to the normal-weight individuals (P<0.05). Furthermore, positive correlations between maternal hepcidin and the majority of maternal thyroid hormones were found, with a most potent relation to FT3 (r=0.40; P<0.01). Interestingly, no alterations of thyroid hormones and iron metabolism parameters were noticed in cord blood in any of the subgroups. In summary, pre-pregnancy obesity is associated with elevated maternal hepcidin, albeit no signs of lowered cord blood iron status were shown. Medical history of hypothyroidism following the restoration of euthyroidism does not substantially influence maternal nor cord blood hepcidin concentration, as well as fetal iron homeostasis, even though free thyroid hormone levels correlate with maternal hepcidin.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.contributor.authorWojciechowska, M.
dc.contributor.authorWisniewski, O.W.
dc.contributor.authorPruszyńska-Oszmałek, Ewa
dc.contributor.authorKrauss, H.
dc.contributor.authorSassek, Maciej
dc.contributor.authorLeciejewska, Natalia
dc.contributor.authorKołodziejski, Paweł
dc.contributor.authorWilczak, M.
dc.date.access2026-03-04
dc.date.accessioned2026-03-09T08:36:36Z
dc.date.available2026-03-09T08:36:36Z
dc.date.copyright2022-10-30
dc.date.issued2022
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,2
dc.description.number5
dc.description.points100
dc.description.versionfinal_published
dc.description.volume73
dc.identifier.doi10.26402/jpp.2022.5.04
dc.identifier.eissn1899-1505
dc.identifier.issn0867-5910
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7721
dc.identifier.weblinkhttps://www.jpp.krakow.pl/
dc.languageen
dc.relation.ispartofJournal of Physiology and Pharmacology
dc.relation.pages605-612
dc.rightsOther
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enhepcidin
dc.subject.enhypothyroidism
dc.subject.eniron homeostasis
dc.subject.eniron metabolism
dc.subject.enobesity
dc.subject.enpregnancy
dc.subject.enthyroid
dc.subject.enumbilical cord blood
dc.subject.enmaternal blood
dc.subject.entriiodothyronine
dc.subject.enthyroxine
dc.subject.enferritin
dc.titleEffect of obesity and hypothyroidism on hepcidin concentration in pregnancy - a pilot study using maternal and umbilical cord blood at delivery day
dc.typeJournalArticle
dspace.entity.typePublication