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Uncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study

cris.lastimport.scopus2025-10-23T06:55:54Z
cris.virtual.author-orcid0000-0002-5127-5173
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid89e157e6-5dac-4b19-bb53-0d4b8eb0a1a9
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enAlthough obesity in the domestic dog (Canis lupus familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically ALPL, KCTD8, SGSM1, SLC12A6, RYR3, and VPS26C, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorAntkowiak, Michał
dc.contributor.authorSzydłowski, Maciej
dc.date.access2025-06-23
dc.date.accessioned2025-09-15T12:31:14Z
dc.date.available2025-09-15T12:31:14Z
dc.date.copyright2023-09-20
dc.date.issued2023
dc.description.abstract<jats:p>Although obesity in the domestic dog (<jats:italic>Canis lupus</jats:italic> familiaris) is known to decrease well-being and shorten lifespan, the genetic risk variants associated with canine obesity remain largely unknown. In our study, which focused on the obesity-prone Labrador Retriever breed, we conducted a genome-wide analysis to identify structural variants linked to body weight and obesity. Obesity status was based on a 5-point body condition score (BCS) and the obese dog group included all dogs with a BCS of 5, along with dogs with the highest body weight within the BCS 4 group. Data from whole-gene sequencing of fifty dogs, including 28 obese dogs, were bioinformatically analyzed to identify potential structural variants that varied in frequency between obese and healthy dogs. The seven most promising variants were further analyzed by droplet digital PCR in a group of 110 dogs, including 63 obese. Our statistical evidence suggests that common structural mutations in or near six genes, specifically <jats:italic>ALPL</jats:italic>, <jats:italic>KCTD8</jats:italic>, <jats:italic>SGSM1</jats:italic>, <jats:italic>SLC12A6</jats:italic>, <jats:italic>RYR3</jats:italic>, and <jats:italic>VPS26C</jats:italic>, may contribute to the variability observed in body weight and body condition scores among Labrador Retriever dogs. These findings emphasize the need for additional research to validate the associations and explore the specific functions of these genes in relation to canine obesity.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,8
dc.description.points140
dc.description.versionfinal_published
dc.description.volume14
dc.identifier.doi10.3389/fgene.2023.1235821
dc.identifier.issn1664-8021
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4800
dc.identifier.weblinkhttps://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1235821/full
dc.languageen
dc.relation.ispartofFrontiers in Genetics
dc.relation.pagesart. 1235821
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enlabrador retriever
dc.subject.enobesity
dc.subject.enALPL
dc.subject.enKCTD8
dc.subject.enSGSM1
dc.subject.enSLC12A6
dc.subject.enRYR3
dc.subject.enVPS26C
dc.titleUncovering structural variants associated with body weight and obesity risk in labrador retrievers: a genome-wide study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume14