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The effect of caffeine dose on caffeine and paraxanthine changes in serum and saliva and CYP1A2 enzyme activity in athletes: a randomized placebo-controlled crossover trial

cris.lastimport.scopus2025-10-23T06:56:41Z
cris.virtual.author-orcid0000-0002-3105-607X
cris.virtual.author-orcid0000-0002-9030-1805
cris.virtual.author-orcid0000-0002-2045-0709
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcida22ee384-520a-4c18-8fa1-456189987c26
cris.virtualsource.author-orcidd9cad178-0d31-4dd0-a418-60d6ed7cfa5d
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid27a945b5-0dd6-465b-9459-95b0fa8038ea
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground Although caffeine (CAF) supplementation has been shown to improve exercise performance, its dose dependent effect on CAF metabolism has not been sufficiently investigated. The aim of this study was to evaluate the effects of 3, 6 and 9 mg of CAF/kgBM on changes of CAF and paraxanthine (PRX) in the serum and saliva at four time-points. Methods In a randomized, double-blind, placebo-controlled crossover design, acute pre-exercise supplementation in 26 moderately-trained athletes, participating in high-intensity functional training (HIFT), was examined. The study protocol involved CAF/PRX biochemical analyses of serum and saliva with respect to CYP1A2 polymorphism and CYP1A2 enzyme activity. Results Despite significant differences between the serum and saliva levels of CAF and PRX, there was no difference in the PRX/CAF ratio. The interaction effect of dose and time-points for PRX oncentration was revealed. The main effects of dose were observed for CAF and the PRX/CAF ratio. The main effect of time-points was registered only for serum CAF. Conclusions Dose- and time-dependent effect of CAF supplementation on CAF and PRX in the serum and saliva of athletes was confirmed, but there was no effect of the CAF dose on CYP1A2 enzyme activity, nor was there an interaction of CYP1A2 with enzyme inducibility. The CAF/PRX correlation indicated the possibility of interchangeable use of serum and/or saliva analyses in exercise studies.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorGłówka, Natalia
dc.contributor.authorMalik, Jakub
dc.contributor.authorAnioła, Jacek
dc.contributor.authorZawieja, Emilia
dc.contributor.authorChmurzyńska, Agata
dc.contributor.authorDurkalec-Michalski, Krzysztof
dc.date.access2024-11-29
dc.date.accessioned2024-12-03T09:28:08Z
dc.date.available2024-12-03T09:28:08Z
dc.date.copyright2024-11-11
dc.date.issued2024
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,9
dc.description.points100
dc.description.versionfinal_published
dc.description.volume21
dc.identifier.doi10.1186/s12986-024-00863-3
dc.identifier.issn1743-7075
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2152
dc.identifier.weblinkhttps://nutritionandmetabolism.biomedcentral.com
dc.languageen
dc.relation.ispartofNutrition and Metabolism
dc.relation.pagesart. 90
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enenzyme activity
dc.subject.energogenic support
dc.subject.enhigh-intensity functional training
dc.subject.enmetabolism
dc.subject.ensports dietetics
dc.subject.ensupplementation
dc.titleThe effect of caffeine dose on caffeine and paraxanthine changes in serum and saliva and CYP1A2 enzyme activity in athletes: a randomized placebo-controlled crossover trial
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume21