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Effect of clinically uneventful carotid endarterectomy on pentraxin 3 concentration: relationships between cognitive functions, local inflammation, and duration of brain ischemia

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cris.virtual.author-orcid0000-0002-7182-6905
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cris.virtual.author-orcid0000-0003-0715-0223
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cris.virtualsource.author-orcid0c22ceb5-e5c6-4f5d-a0fd-8ec91a16efa9
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dc.abstract.enIntroduction: The pentraxins are a superfamily of proteins characterized by the presence of a pentraxin domain at the C-terminal. One of them is pentraxin 3 (PTX3), which is of great interest to scientists, primarily due to its function as an endogenous modulator of the inflammatory response. Local inflammation is a common phenomenon during various types of surgery and procedures, and its causes, among others, are local ischemia or tissue irritation. One such procedure is carotid plaque removal by carotid endarterectomy (CEA), which is performed to reduce the risk of stroke. Material and methods: The purpose of this study was to investigate the effect of CEA on PTX3 concentration and the relationship between cognitive functions and the duration of brain ischemia in patients. We evaluated the relationships using blood collected from patients undergoing CEA, the Mini-Mental State Examination (MMSE) questionnaire, and commercially available ELISA tests. Results: Results: We found that the concentration of PTX3 increased after surgery (from 0.59 ± 0.11 to 1.29 ± 0.29 ng mL–1; P < 0.01). Also, a decrease in the MMSE score was observed 24 hours after the procedure (P < 0.01). However, just one month after the procedure, it significantly increased compared to the day of admission to the hospital (P < 0.01). Our results did not demonstrate any interactions between the tested parameters. It can be concluded that neither the changes in PTX3 concentration following the procedure nor the timing of these changes directly contribute to the temporary deterioration of cognitive functions observed after CEA. Conclusions: PTX3 increases independently of the duration of cerebral hypoxemia/ hypercapnia after clamping the carotid artery. This rise is an inflammatory marker that occurs independently within the central nervous system.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Fizjologii, Biochemii i Biostruktury Zwierząt
dc.contributor.authorRękas-Dudziak, Anna Renata
dc.contributor.authorRojek, Joanna
dc.contributor.authorBlacha, Anna
dc.contributor.authorPruszyńska-Oszmałek, Ewa
dc.contributor.authorKołodziejski, Paweł
dc.contributor.authorMatuła, Przemysław
dc.date.access2025-07-07
dc.date.accessioned2025-07-07T12:22:53Z
dc.date.available2025-07-07T12:22:53Z
dc.date.copyright2025-06-18
dc.date.issued2025
dc.description.abstract<jats:sec><jats:title>Introduction</jats:title><jats:p>The pentraxins are a superfamily of proteins characterized by the presence of a pentraxin domain at the C-terminal. One of them is pentraxin 3 (PTX3), which is of great interest to scientists, primarily due to its function as an endogenous modulator of the inflammatory response. Local inflammation is a common phenomenon during various types of surgery and procedures, and its causes, among others, are local ischemia or tissue irritation. One such procedure is carotid plaque removal by carotid endarterectomy (CEA), which is performed to reduce the risk of stroke.</jats:p></jats:sec><jats:sec><jats:title>Material and methods</jats:title><jats:p>The purpose of this study was to investigate the effect of CEA on PTX3 concentration and the relationship between cognitive functions and the duration of brain ischemia in patients. We evaluated the relationships using blood collected from patients undergoing CEA, the Mini-Mental State Examination (MMSE) questionnaire, and commercially available ELISA tests.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Results: We found that the concentration of PTX3 increased after surgery (from 0.59 ± 0.11 to 1.29 ± 0.29 ng mL&lt;sup&gt;–1&lt;/sup&gt;; &lt;i&gt;P&lt;/i&gt; &lt; 0.01). Also, a decrease in the MMSE score was observed 24 hours after the procedure (&lt;i&gt;P&lt;/i&gt; &lt; 0.01). However, just one month after the procedure, it significantly increased compared to the day of admission to the hospital (&lt;i&gt;P&lt;/i&gt; &lt; 0.01). Our results did not demonstrate any interactions between the tested parameters. It can be concluded that neither the changes in PTX3 concentration following the procedure nor the timing of these changes directly contribute to the temporary deterioration of cognitive functions observed after CEA.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>PTX3 increases independently of the duration of cerebral hypoxemia/ hypercapnia after clamping the carotid artery. This rise is an inflammatory marker that occurs independently within the central nervous system.</jats:p></jats:sec>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if1,7
dc.description.number1
dc.description.points70
dc.description.versionfinal_published
dc.description.volume57
dc.identifier.doi10.5114/ait/203169
dc.identifier.eissn1731-2531
dc.identifier.issn1642-5758
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/3819
dc.identifier.weblinkhttps://www.ait-journal.com/Effect-of-clinically-uneventful-carotid-endarterectomy-on-pentraxin-3-concentration,203169,0,2.html
dc.languageen
dc.relation.ispartofAnaesthesiology Intensive Therapy
dc.relation.pages121-127
dc.rightsCC-BY-NC-SA
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enpentraxin 3
dc.subject.encarotid endarterectomy
dc.subject.enlocal inflamatory
dc.titleEffect of clinically uneventful carotid endarterectomy on pentraxin 3 concentration: relationships between cognitive functions, local inflammation, and duration of brain ischemia
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume57