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Calcium-Deficit Diet Improves Iron Content in Ovariectomized Rats

cris.virtual.author-orcid0000-0002-0937-8427
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cris.virtual.author-orcid0000-0002-0744-9033
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
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cris.virtualsource.author-orcid968d3cb8-3b2b-46fe-a17f-373169a0738c
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enIn women, menopause is associated with disorders related to calcium and iron content, which may increase the risk of osteoporosis. This study aimed to determine the effect of calcium deficiency on the iron content in ovariectomized rats. This study included 30 3-month-old female rats, which were divided into three groups: group C (n = 10)—control group fed the standard diet; group O—ovariectomized rats fed the standard diet; and group D—ovariectomized rats fed the calcium-deficit diet. After 3 months of experimental intervention, the weight of the rats was measured, and blood and tissue samples were collected. Morphological parameters were analyzed in whole blood, and serum levels of leptin, estrogen and C-reactive protein, and total antioxidant status were determined. The iron content was measured in tissues, and histological analysis was performed in the femur. The results obtained demonstrated that ovariectomy significantly decreased the iron content in bones, hair, spleen, liver, and kidneys. The calcium-deficit diet increased the iron content in tissues and the hemoglobin level in ovariectomized rats and also enhanced the number of osteoblasts in bones compared with the O group. In conclusion, calcium deficiency improved the iron content in ovariectomized rats in this 12-week study.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Technologii Gastronomicznej i Żywności Funkcjonalnej
dc.contributor.authorSuliburska, Joanna
dc.contributor.authorWawrzyniak, Natalia
dc.contributor.authorGramza-Michałowska, Anna
dc.contributor.authorKurzawa, Paweł
dc.date.access2024-09-12
dc.date.accessioned2024-10-16T11:08:32Z
dc.date.available2024-10-16T11:08:32Z
dc.date.copyright2023-01-10
dc.date.issued2023
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>In women, menopause is associated with disorders related to calcium and iron content, which may increase the risk of osteoporosis. This study aimed to determine the effect of calcium deficiency on the iron content in ovariectomized rats. This study included 30 3-month-old female rats, which were divided into three groups: group C (<jats:italic>n</jats:italic> = 10)—control group fed the standard diet; group O—ovariectomized rats fed the standard diet; and group D—ovariectomized rats fed the calcium-deficit diet. After 3 months of experimental intervention, the weight of the rats was measured, and blood and tissue samples were collected. Morphological parameters were analyzed in whole blood, and serum levels of leptin, estrogen and C-reactive protein, and total antioxidant status were determined. The iron content was measured in tissues, and histological analysis was performed in the femur. The results obtained demonstrated that ovariectomy significantly decreased the iron content in bones, hair, spleen, liver, and kidneys. The calcium-deficit diet increased the iron content in tissues and the hemoglobin level in ovariectomized rats and also enhanced the number of osteoblasts in bones compared with the O group. In conclusion, calcium deficiency improved the iron content in ovariectomized rats in this 12-week study.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,4
dc.description.number10
dc.description.points70
dc.description.versionfinal_published
dc.description.volume201
dc.identifier.doi10.1007/s12011-023-03556-9
dc.identifier.eissn1559-0720
dc.identifier.issn0163-4984
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1851
dc.languageen
dc.relation.ispartofBiological Trace Element Research
dc.relation.pages4806-4811
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOTHER
dc.subject.enOvariectomy
dc.subject.enIron
dc.subject.enCalcium
dc.subject.enRat
dc.titleCalcium-Deficit Diet Improves Iron Content in Ovariectomized Rats
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume201