Simple item page
 

Influence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high-fat iron-deficient diet

cris.lastimport.scopus2025-10-23T06:59:32Z
cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0001-8417-2245
cris.virtual.author-orcid0000-0002-5418-5632
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcidedf63522-bb89-4788-a8d3-9c3f3858875b
cris.virtualsource.author-orcidccd52a90-8355-4384-b6ea-c94578ebf2ce
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBACKGROUND A high-fat (HF) diet, diet iron deficiency and iron supplementation may affect inflammatory parameters. Probiotics influence both iron metabolism and inflammation. We compared the inflammatory state in rats on a HF iron-deficient diet receiving oral iron, Lactobacillus plantarum and Lactobacillus curvatus in different combinations. METHODS This was a two-stage experiment. In groups C (n = 8) and HF (n = 8), rats ate a control or HF diet, respectively, for 16 weeks. In the group HFDEF (n = 48), rats ate a HF iron-deficient diet for 8 weeks (first stage) and were subsequently divided into 6 groups (n = 8 each) receiving the following for a further 8 weeks (second stage): HFDEF – a HF iron-deficient diet; HFDEFFe – a HF iron-deficient diet with iron; HFDEFLp and HFDEFLc – a HF iron-deficient diet with L. plantarum or L. curvatus, respectively; and HFDEFFeLp and HFDEFFeLc – a HF iron-deficient diet with iron and L. plantarum or L. curvatus, respectively. Body composition analysis and blood sampling was performed. Markers of iron status and levels of total antioxidant status (TAS), C-reactive protein (CRP), tumour necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were measured in the blood. RESULTS TAS was higher in the HFDEF group (756.57 ± 489.53 ng mL−1) versus the HFDEFLc group (187.04 ± 47.84 ng mL−1; P = 0.022). No more differences were found between groups, or in TAS, CRP, TNF-α and IL-6 concentrations. Also, no differences were found between groups for alanine and aspartate aminotransferases, glucose, total cholesterol, low- and high-density lipoproteins and triglycerides. TAS level was positively correlated with ferritin concentration, IL-6 with TAS and TNF-α with hepcidin level. CONCLUSIONS Supplementation with L. plantarum, L. curvatus and iron in combinations exerts no influence on inflammatory status, lipid profile, hepatic function and serum fasting glucose in rats on a HF iron-deficient diet. © 2024 Society of Chemical Industry.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.affiliation.instituteKatedra Biotechnologii i Mikrobiologii Żywności
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorSchmidt, Marcin
dc.contributor.authorOlejnik-Schmidt, Agnieszka
dc.contributor.authorHarahap, Iskandar Azmy
dc.contributor.authorSuliburska, Joanna
dc.date.accessioned2025-02-26T08:31:46Z
dc.date.available2025-02-26T08:31:46Z
dc.date.issued2024
dc.description.abstract<jats:title>Abstract</jats:title><jats:sec><jats:title>BACKGROUND</jats:title><jats:p>A high‐fat (HF) diet, diet iron deficiency and iron supplementation may affect inflammatory parameters. Probiotics influence both iron metabolism and inflammation. We compared the inflammatory state in rats on a HF iron‐deficient diet receiving oral iron, <jats:italic>Lactobacillus plantarum</jats:italic> and <jats:italic>Lactobacillus curvatus</jats:italic> in different combinations.</jats:p></jats:sec><jats:sec><jats:title>METHODS</jats:title><jats:p>This was a two‐stage experiment. In groups C (<jats:italic>n</jats:italic> = 8) and HF (<jats:italic>n</jats:italic> = 8), rats ate a control or HF diet, respectively, for 16 weeks. In the group HFDEF (<jats:italic>n</jats:italic> = 48), rats ate a HF iron‐deficient diet for 8 weeks (first stage) and were subsequently divided into 6 groups (<jats:italic>n</jats:italic> = 8 each) receiving the following for a further 8 weeks (second stage): HFDEF – a HF iron‐deficient diet; HFDEFFe – a HF iron‐deficient diet with iron; HFDEFLp and HFDEFLc – a HF iron‐deficient diet with <jats:italic>L. plantarum</jats:italic> or <jats:italic>L. curvatus</jats:italic>, respectively; and HFDEFFeLp and HFDEFFeLc – a HF iron‐deficient diet with iron and <jats:italic>L. plantarum</jats:italic> or <jats:italic>L. curvatus</jats:italic>, respectively. Body composition analysis and blood sampling was performed. Markers of iron status and levels of total antioxidant status (TAS), C‐reactive protein (CRP), tumour necrosis factor alpha (TNF‐<jats:italic>α</jats:italic>) and interleukin 6 (IL‐6) were measured in the blood.</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>TAS was higher in the HFDEF group (756.57 ± 489.53 ng mL<jats:sup>−1</jats:sup>) <jats:italic>versus</jats:italic> the HFDEFLc group (187.04 ± 47.84 ng mL<jats:sup>−1</jats:sup>; <jats:italic>P</jats:italic> = 0.022). No more differences were found between groups, or in TAS, CRP, TNF‐<jats:italic>α</jats:italic> and IL‐6 concentrations. Also, no differences were found between groups for alanine and aspartate aminotransferases, glucose, total cholesterol, low‐ and high‐density lipoproteins and triglycerides. TAS level was positively correlated with ferritin concentration, IL‐6 with TAS and TNF‐<jats:italic>α</jats:italic> with hepcidin level.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSIONS</jats:title><jats:p>Supplementation with <jats:italic>L. plantarum</jats:italic>, <jats:italic>L. curvatus</jats:italic> and iron in combinations exerts no influence on inflammatory status, lipid profile, hepatic function and serum fasting glucose in rats on a HF iron‐deficient diet. © 2024 Society of Chemical Industry.</jats:p></jats:sec>
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,5
dc.description.number7
dc.description.points100
dc.description.volume104
dc.identifier.doi10.1002/jsfa.13329
dc.identifier.eissn1097-0010
dc.identifier.issn0022-5142
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2518
dc.languageen
dc.pbn.affiliationfood and nutrition technology
dc.relation.ispartofJournal of the Science of Food and Agriculture
dc.relation.pages4411-4424
dc.relation.projectBadanie wpływu Lactobacillus plantarum ATCC14917 na gospodarkę żelaza u szczurów na diecie wysokotłuszczowej
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.eniron
dc.subject.enprobiotics
dc.subject.eninflammatory status
dc.subject.eniron-deficient diet
dc.titleInfluence of supplementation with iron and probiotic bacteria Lactobacillus plantarum and Lactobacillus curvatus on selected parameters of inflammatory state in rats on a high-fat iron-deficient diet
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue7
oaire.citation.volume104