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The Enhanced Expression of ZWILCH Predicts Poor Survival of Adrenocortical Carcinoma Patients

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dc.abstract.enZwilch kinetochore protein (ZWILCH) plays a key role in proper cell proliferation. The upregulation of the ZWILCH gene was observed in many types of cancers, but the association of ZWILCH with adrenocortical carcinoma (ACC) was not investigated so far. The main aim of the presented study was to verify if the enhanced level of the ZWILCH gene can be used as a diagnostic marker for ACC development and progression, as well as a predictor of survival time for ACC patients. The performed analyses included investigation of the ZWILCH expression profile in tumors with publicly available TCGA (The Cancer Genome Atlas) datasets and transcriptomic data from the Gene Expression Omnibus (GEO) database, as well as, in human biological samples of normal adrenal, adrenocortical carcinoma and in commercially available tissue microarrays. The findings demonstrate statistically significant higher ZWILCH gene expression in ACC tissue in comparison with normal adrenal glands. Furthermore, there is a strong correlation between ZWILCH upregulation and tumor mitotic rate and the probability of patient survival. The enhanced ZWILCH level is also connected with the activation of genes involved in cell proliferation and the inhibition of genes related to the immune system. This work contributes to a better understanding of the role of ZWILCH as an ACC biomarker and diagnostic tool.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorBlatkiewicz, Małgorzata
dc.contributor.authorKamiński, Kacper
dc.contributor.authorSzyszka, Marta
dc.contributor.authorAl-Shakarchi, Zaid
dc.contributor.authorOlechnowicz, Anna
dc.contributor.authorStelcer, Ewelina
dc.contributor.authorKomarowska, Hanna
dc.contributor.authorTyczewska, Marianna
dc.contributor.authorKlimont, Anna
dc.contributor.authorKarczewski, Marek
dc.contributor.authorWierzbicki, Tomasz
dc.contributor.authorMikołajczyk-Stecyna, Joanna
dc.contributor.authorRuchała, Marek
dc.contributor.authorMalendowicz, Ludwik K.
dc.contributor.authorRuciński, Marcin
dc.date.access2025-06-06
dc.date.accessioned2025-09-17T11:20:40Z
dc.date.available2025-09-17T11:20:40Z
dc.date.copyright2023-04-21
dc.date.issued2023
dc.description.abstract<jats:p>Zwilch kinetochore protein (ZWILCH) plays a key role in proper cell proliferation. The upregulation of the ZWILCH gene was observed in many types of cancers, but the association of ZWILCH with adrenocortical carcinoma (ACC) was not investigated so far. The main aim of the presented study was to verify if the enhanced level of the ZWILCH gene can be used as a diagnostic marker for ACC development and progression, as well as a predictor of survival time for ACC patients. The performed analyses included investigation of the ZWILCH expression profile in tumors with publicly available TCGA (The Cancer Genome Atlas) datasets and transcriptomic data from the Gene Expression Omnibus (GEO) database, as well as, in human biological samples of normal adrenal, adrenocortical carcinoma and in commercially available tissue microarrays. The findings demonstrate statistically significant higher ZWILCH gene expression in ACC tissue in comparison with normal adrenal glands. Furthermore, there is a strong correlation between ZWILCH upregulation and tumor mitotic rate and the probability of patient survival. The enhanced ZWILCH level is also connected with the activation of genes involved in cell proliferation and the inhibition of genes related to the immune system. This work contributes to a better understanding of the role of ZWILCH as an ACC biomarker and diagnostic tool.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if3,9
dc.description.number4
dc.description.points100
dc.description.versionfinal_published
dc.description.volume11
dc.identifier.doi10.3390/biomedicines11041233
dc.identifier.issn2227-9059
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4884
dc.identifier.weblinkhttps://www.mdpi.com/2227-9059/11/4/1233
dc.languageen
dc.relation.ispartofBiomedicines
dc.relation.pagesart. 1233
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enadrenocortical carcinoma
dc.subject.enadenoma
dc.subject.engenetics
dc.subject.enadrenal
dc.subject.enZWILCH gene
dc.titleThe Enhanced Expression of ZWILCH Predicts Poor Survival of Adrenocortical Carcinoma Patients
dc.title.volumeSpecial Issue Pathogenesis and Treatment of Adrenal Tumors 2.0
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue4
oaire.citation.volume11