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The Effect of Black Chokeberry (Aronia melanocarpa) on Human Inflammation Biomarkers and Antioxidant Enzymes: A Systematic Review of Randomized Controlled Trials

dc.affiliationWydział Rolnictwa, Ogrodnictwa i Bioinżynierii
dc.affiliation.instituteKatedra Biochemii i Biotechnologii
dc.contributor.authorSarıkaya, Buse
dc.contributor.authorKolay, Ezgi
dc.contributor.authorGuney-Coskun, Merve
dc.contributor.authorYigit Ziolkowski, Asli
dc.contributor.authorAktaç, Şule
dc.date.accessioned2025-08-04T12:18:11Z
dc.date.available2025-08-04T12:18:11Z
dc.date.issued2024
dc.description.abstract<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Context</jats:title> <jats:p>Consuming antioxidant-rich foods has been associated with potential benefits in managing chronic diseases by reducing oxidative stress and inflammation.</jats:p> </jats:sec> <jats:sec> <jats:title>Objective</jats:title> <jats:p>This systematic review aimed to evaluate the effects of Aronia melanocarpa (aronia berry or chokeberry) on human inflammation biomarkers and antioxidant enzymes.</jats:p> </jats:sec> <jats:sec> <jats:title>Data Sources</jats:title> <jats:p>A systematic search was conducted across multiple databases, including PubMed, Scopus, Science Direct, and Web of Science, to identify relevant studies investigating the potential effects of aronia on human inflammation biomarkers and antioxidant enzymes between April 2022 and November 2023.</jats:p> </jats:sec> <jats:sec> <jats:title>Data Extraction</jats:title> <jats:p>The selection of studies followed the PRISMA guidelines, data screening was conducted by 4 independent reviewers, and data extraction and risk-of-bias assessments were performed by 2 independent reviewers using the Cochrane Risk of Bias 2 tool.</jats:p> </jats:sec> <jats:sec> <jats:title>Data Analysis</jats:title> <jats:p>A total of 1986 studies were screened, and 18 studies that met the inclusion criteria were included in a systematic review that investigated the anti-inflammatory effects of aronia on various health parameters. These studies primarily focused on the effects of aronia on cardiometabolic diseases, performance in sport, and other health parameters.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>This study examined the effects of Aronia intervention on human health outcomes using aronia juice, extract, or oven-dried powder for a period of 4 to 13 weeks. The primary health parameters considered were C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-8 (IL-8), interleukin-10 (IL-10), interleukin-1ß (IL-1ß), superoxide dismutase (SOD), catalase (CAT), and reduced glutathione peroxidase (GSH-Px). The results showed that aronia had a beneficial effect on several inflammatory cytokines, including reductions in CRP, TNF-α and IL-6 concentrations, as well as elevated IL-10 levels. Moreover, positive changes have been observed in antioxidant enzyme systems, including; elevated SOD, GSH-Px and CAT activity. The findings of the presented studies provide evidence that Aronia melanocarpa may have beneficial effects on inflammatory markers.</jats:p> </jats:sec> <jats:sec> <jats:title>Systematic Review Registration</jats:title> <jats:p>PROSPERO registration No. CRD42022325633.</jats:p> </jats:sec>
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,9
dc.description.number6
dc.description.points140
dc.description.volume83
dc.identifier.doi10.1093/nutrit/nuae143
dc.identifier.eissn1753-4887
dc.identifier.issn0029-6643
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/4069
dc.languageen
dc.relation.ispartofNutrition Reviews
dc.relation.pages1083-1098
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enantioxidants
dc.subject.enAronia melanocarpa
dc.subject.enblack chokeberry
dc.subject.eninflammation
dc.subtypeReviewArticle
dc.titleThe Effect of Black Chokeberry (Aronia melanocarpa) on Human Inflammation Biomarkers and Antioxidant Enzymes: A Systematic Review of Randomized Controlled Trials
dc.typeJournalArticle
dspace.entity.typePublication