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Withdrawal periods after treatment of pigs with oxytetracycline in- and outside the European Union

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dc.abstract.enWithdrawal periods are used to avoid animals being delivered to slaughter before the concentration of the antimicrobial has declined to values below the maximum residue limit (MRL). This paper characterises the withdrawal periods in force for oxytetracycline 100 mg/ml for intramuscular use in pigs. We investigated the variation in duration of the withdrawal period between 68 oxytetracycline products from 29 countries in- and outside the European Union. More specifically, we tested whether there is a regional difference, a difference between major and minor pig meat exporting countries, whether the product is long-acting or not, and whether year of market authorisation correlated with the withdrawal period. The results showed a large variation in duration of the withdrawal periods, ranging from 5 to 40 days. Variation was observed both between and within countries. Moreover, major exporting countries were associated with a longer withdrawal period than minor exporting countries (P = 0.00099). There were no regional differences, and the year of market authorisation had no impact, but long-acting products had a shorter withdrawal period than short-acting products (P = 0.048). The variation in withdrawal periods observed questions the utility of using compliance with the withdrawal period as a means of assessing whether the meat is safe for consumption. This is particularly relevant when a pig producer unintentionally delivers pigs for slaughter before the withdrawal period has expired and, aware of this, informs the abattoir. The findings call for further harmonisation in determining the withdrawal periods for all veterinary medicinal products (VMP). Until this happens, if animals are prematurely sent to slaughter, we suggest that the concentration of the VMP at the time of slaughter is calculated and compared with the MRL to determine meat safety.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Hodowli Zwierząt i Oceny Surowców
dc.contributor.authorLund, Daniel Hjorth
dc.contributor.authorPetersen, Jesper Valentin
dc.contributor.authorAntunovic, Boris
dc.contributor.authorBelous, Madalina
dc.contributor.authorBonardi, Silvia
dc.contributor.authorGarcía-Gimeno, Rosa Maria
dc.contributor.authorJenson, Ian
dc.contributor.authorKautto, Arja H.
dc.contributor.authorMajewski, Michał
dc.contributor.authorOorburg, Derk
dc.contributor.authorSakaridis, Ioannis
dc.contributor.authorSirbu, Alexandrina
dc.contributor.authorVieira-Pinto, Madalena
dc.contributor.authorVågsholm, Ivar
dc.contributor.authorAlban, Lis
dc.date.access2024-11-26
dc.date.accessioned2024-11-26T13:32:09Z
dc.date.available2024-11-26T13:32:09Z
dc.date.copyright2023-09-07
dc.date.issued2024
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,6
dc.description.points140
dc.description.reviewreview
dc.description.versionfinal_published
dc.description.volume155
dc.identifier.doi10.1016/j.foodcont.2023.110071
dc.identifier.issn0956-7135
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2090
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S0956713523004711
dc.languageen
dc.relation.ispartofFood Control
dc.relation.pagesart. 110071
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOTHER
dc.subject.enmeat safety
dc.subject.enantimicrobial
dc.subject.enmaximum residue limit
dc.subject.enwithdrawal period
dc.subject.enacceptable daily intake
dc.subject.enrisk management
dc.subject.enharmonisation
dc.titleWithdrawal periods after treatment of pigs with oxytetracycline in- and outside the European Union
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume155