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Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations

cris.virtual.author-orcid0000-0002-9030-1805
cris.virtual.author-orcid0000-0002-2045-0709
cris.virtualsource.author-orcidd9cad178-0d31-4dd0-a418-60d6ed7cfa5d
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
dc.abstract.enThe rapid aging of the global population necessitates addressing age-related conditions through innovative strategies. Nutritional supplements have emerged as potential interventions for preventing or slowing age-related changes, with betaine being a promising candidate. This systematic review aims to provide a comprehensive analysis of current literature on the impact of betaine on the aging process. Specifically, we summarize the mechanisms through which betaine is proposed to affect aging, we integrate existing findings, we identify gaps in the literature, and we discuss practical implications for promoting healthy aging. Evidence suggests that betaine may counteract aging-related changes in methylation potential by increasing concentration of S-adenosylmethionine, a key methyl donor. Additionally, betaine reduces homocysteine concentrations, potentially mitigating vascular, neurodegenerative, and oxidative damage. Betaine has also been shown to enhance mitochondrial function, to reduce oxidative stress, and to attenuate inflammation. It may serve as a preventive agent against sarcopenia by promoting anabolic signaling pathways and improving muscle strength in younger adults. Betaine may also exert an effect on bone remodeling and adipose tissue metabolism, with animal studies indicating enhanced fat oxidation and reduced fat synthesis. Although certain limited studies have suggested betaine’s potential in mitigating age-related neurodegenerative diseases, the currently available evidence does not establish a clear link between dietary betaine intake and the incidence of cardiovascular diseases or type-2 diabetes. In conclusion, emerging evidence highlights the potential of betaine in attenuating age-related changes. However, further research is required to elucidate the efficacy and safety of betaine supplementation in older populations.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorZawieja, Emilia
dc.contributor.authorChmurzyńska, Agata
dc.date.accessioned2025-01-09T11:43:19Z
dc.date.available2025-01-09T11:43:19Z
dc.date.issued2025
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if12,5
dc.description.numberFebruary 2025
dc.description.points140
dc.description.reviewreview
dc.description.volume104
dc.identifier.doi10.1016/j.arr.2024.102634
dc.identifier.eissn1872-9649
dc.identifier.issn1568-1637
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/2311
dc.languageen
dc.relation.ispartofAgeing Research Reviews
dc.relation.pagesart. 102634
dc.rightsClosedAccess
dc.sciencecloudsend
dc.subject.enbetaine
dc.subject.enaging
dc.subject.enmethylation
dc.subject.enneurodegeneration
dc.subject.enhomocysteine
dc.subject.enone-carbon metabolism
dc.subtypeReviewArticle
dc.titleBetaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume104