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The influence of multi-strain probiotic supplementation on calcium and magnesium status in women with non-morbid obesity

cris.virtual.author-orcid0000-0002-4173-5965
cris.virtual.author-orcid0000-0002-0937-8427
cris.virtual.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
cris.virtualsource.author-orcidc8f75a2c-3403-4f93-aa73-6cf0ae8b543d
cris.virtualsource.author-orcid31a85399-18e5-444d-b0c6-96b441dd2551
cris.virtualsource.author-orcid#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.abstract.enBackground. Obesity is a significant global health issue, associated with many metabolic disorders. Mag­nesium (Mg) and calcium (Ca) play critical roles in body metabolism, and deficiencies in these minerals can increase complications associated with obesity. This study aimed to investigate the effects of twelve weeks of multi-strain probiotic supplementation on Ca and Mg metabolism in obese women. Material and methods. The study is a multicentre, randomised, double-blind, placebo-controlled trial con­ducted at the University of Medical Sciences in Poznań and the University of Life Sciences in Poznań. Ninety obese women, aged 45–70, with a BMI > 30 kg/m², participated in the study. Participants were randomly as­signed to either a high-dose (HD) or low-dose (LD) probiotic or placebo group. The probiotic groups received the Ecologic Barrier multi-strain probiotic combination. Results. Hair Ca concentration was significantly lower in the LD group after the intervention (p < 0.05), while no significant changes were observed in serum calcium or magnesium levels. Additionally, osteocalcin levels were significantly decreased in the HD group compared to baseline (p < 0.05), indicating a potential effect of probiotics on bone metabolism. No significant differences were observed in oestradiol (E2), para­thyroid hormone (PTH), or Procollagen Type 1 N-Terminal Propeptide (PINP) levels between the baseline and post-intervention. Conclusion. The probiotic supplementation may influence calcium metabolism and bone turnover, as re­flected in changes in hair calcium and osteocalcin levels. Further research is needed to explore the underlying mechanisms and their long-term clinical relevance.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorSkrypnik, Katarzyna
dc.contributor.authorSelvan, Damla
dc.contributor.authorSuliburska, Joanna
dc.date.access2025-11-18
dc.date.accessioned2025-11-18T10:16:53Z
dc.date.available2025-11-18T10:16:53Z
dc.date.copyright2025-09-29
dc.date.issued2025
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if0,8
dc.description.number4
dc.description.points40
dc.description.versionfinal_published
dc.description.volume24
dc.identifier.doi10.17306/J.AFS.001446
dc.identifier.eissn1898-9594
dc.identifier.issn1644-0730
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5950
dc.identifier.weblinkhttp://www.food.actapol.net/volume24/issue4/abstract-7.html
dc.languageen
dc.relation.ispartofActa Scientiarum Polonorum, Technologia Alimentaria
dc.relation.pages537-552
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enobesity
dc.subject.encalcium
dc.subject.enmagnesium
dc.subject.enprobiotic
dc.titleThe influence of multi-strain probiotic supplementation on calcium and magnesium status in women with non-morbid obesity
dc.typeJournalArticle
dspace.entity.typePublication