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Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19

dc.abstract.enBackground: Severe outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. Methods: In this study, a subset of 747 samples from unrelated individuals collected across Poland in 2020 and 2021 was used and whole-genome sequencing was performed. Results: The GWAS analysis of SNPs and short indels located in genes related to CVD identified one variant significant in COVID-19 severe outcome in the HADHA gene, while for the PD gene panel, we found two significant variants in the DRC1 gene. In this study, both potentially protective and risk variants were identified, of which variants in the HADHA gene deserve the most attention. Conclusions: This is the first study reporting the association between the HADHA and DRC1 genetic variants and COVID-19 severe outcome based on the cohort WGS analysis. Although all the identified variants are localised in introns, they may be correlated and therefore inherited along with other risk variants, potentially causative to severe outcome of COVID-19 but not discovered yet.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorSypniewski, Mateusz
dc.contributor.authorKról, Zbigniew J.
dc.contributor.authorSzyda, Joanna
dc.contributor.authorKaja, Elżbieta
dc.contributor.authorMroczek, Magdalena
dc.contributor.authorSuchocki, Tomasz
dc.contributor.authorLejman, Adrian
dc.contributor.authorStępień, Maria
dc.contributor.authorTopolski, Piotr
dc.contributor.authorDąbrowski, Maciej
dc.contributor.authorKotlarz, Krzysztof
dc.contributor.authorAplas, Angelika
dc.contributor.authorWasiak, Michał
dc.contributor.authorWojtaszewska, Marzena
dc.contributor.authorZawadzki, Paweł
dc.contributor.authorPawlak, Agnieszka
dc.contributor.authorGil, Robert
dc.contributor.authorDobosz, Paula
dc.contributor.authorStojak, Joanna
dc.date.access2026-01-09
dc.date.accessioned2026-01-09T14:05:50Z
dc.date.available2026-01-09T14:05:50Z
dc.date.copyright2022-08-04
dc.date.issued2022
dc.description.abstract<jats:p>Background: Severe outcomes of COVID-19 account for up to 15% of all cases. The study aims to check if any gene variants related to cardiovascular (CVD) and pulmonary diseases (PD) are correlated with a severe outcome of COVID-19 in a Polish cohort of COVID-19 patients. Methods: In this study, a subset of 747 samples from unrelated individuals collected across Poland in 2020 and 2021 was used and whole-genome sequencing was performed. Results: The GWAS analysis of SNPs and short indels located in genes related to CVD identified one variant significant in COVID-19 severe outcome in the HADHA gene, while for the PD gene panel, we found two significant variants in the DRC1 gene. In this study, both potentially protective and risk variants were identified, of which variants in the HADHA gene deserve the most attention. Conclusions: This is the first study reporting the association between the HADHA and DRC1 genetic variants and COVID-19 severe outcome based on the cohort WGS analysis. Although all the identified variants are localised in introns, they may be correlated and therefore inherited along with other risk variants, potentially causative to severe outcome of COVID-19 but not discovered yet.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if5,6
dc.description.number15
dc.description.points140
dc.description.versionfinal_published
dc.description.volume23
dc.identifier.doi10.3390/ijms23158696
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6689
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/23/15/8696
dc.languageen
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pagesart. 8696
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.encardiovascular diseases
dc.subject.enpulmonary diseases
dc.subject.engenetic variants
dc.subject.enrisk factors
dc.subject.enCOVID-19
dc.subject.enGWAS
dc.subject.ensingle nucleotide polymorphism
dc.titleGene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19
dc.title.volumeSpecial Issue Animal and Plant Cell–Tissue, Organ Specialization and Function: Investigational, Experimental and Medical Aspects 3.0
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue15
oaire.citation.volume23