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Clinical evaluation of polyunsaturated fatty acids in combination with palmitoylethanolamide (PEA) in the treatment of signs of atopic dermatitis in dogs: Pilot study

cris.virtual.author-orcid0000-0003-1630-2938
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cris.virtualsource.author-orcid527456dc-1715-40e8-bbcd-4761fce356aa
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dc.abstract.enAtopic dermatitis is the most common allergic disease in dogs. The main sign of the disease is severe pruritus, whereas potential therapies include treatment of the causes and symptomatic treatment. The latter involves the use of glucocorticosteroids, oclacitinib, and lokivetmab, but less severe signs can be treated with polyunsaturated fatty acids, antihistamines, cannabidol, or palmitoylethanolamide. The purpose of the study was to evaluate the effectiveness of palmitoylethanolamide combined with polyunsaturated fatty acids in the symptomatic treatment of atopic dermatitis in dogs. The study was performed on 10 dogs. The study arm received palmitoylethanolamide in combination with polyunsaturated fatty acids. In all animals, the intensity of pruritus (pVAS) and the severity of skin lesions (CADESI 04) were assessed six times at weekly intervals. In the study arm, there was a statistically significant reduction in pruritus after 4 weeks of treatment, and a reduction in skin lesions was achieved after 3 weeks of treatment. Palmitoylethanolamide combined with polyunsaturated fatty acids effectively reduces the intensity of skin lesions and pruritus.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.contributor.authorSzczepaniak, Marcin
dc.contributor.authorPomorska-Handwerker, Dorota
dc.contributor.authorJank, Michał
dc.contributor.authorKurosad, Agnieszka
dc.date.access2025-11-18
dc.date.accessioned2025-11-18T10:55:48Z
dc.date.available2025-11-18T10:55:48Z
dc.date.copyright2025-06-20
dc.date.issued2025
dc.description.abstract<jats:p>Atopic dermatitis is the most common allergic disease in dogs. The main sign of the disease is severe pruritus, whereas potential therapies include treatment of the causes and symptomatic treatment. The latter involves the use of glucocorticosteroids, oclacitinib, and lokivetmab, but less severe signs can be treated with polyunsaturated fatty acids, antihistamines, cannabidol, or palmitoylethanolamide. The purpose of the study was to evaluate the effectiveness of palmitoylethanolamide combined with polyunsaturated fatty acids in the symptomatic treatment of atopic dermatitis in dogs. The study was performed on 10 dogs. The study arm received palmitoylethanolamide in combination with polyunsaturated fatty acids. In all animals, the intensity of pruritus (pVAS) and the severity of skin lesions (CADESI 04) were assessed six times at weekly intervals. In the study arm, there was a statistically significant reduction in pruritus after 4 weeks of treatment, and a reduction in skin lesions was achieved after 3 weeks of treatment. Palmitoylethanolamide combined with polyunsaturated fatty acids effectively reduces the intensity of skin lesions and pruritus.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if0,4
dc.description.number12
dc.description.points70
dc.description.versionfinal_published
dc.description.volume81
dc.identifier.doi10.21521/mw.7051
dc.identifier.issn0025-8628
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5955
dc.identifier.weblinkhttp://www.medycynawet.edu.pl/archives/summary/972-summary-2025/992-summary-122025/7051-summary-med-weter-81-10-7051-2025
dc.languageen
dc.relation.ispartofMedycyna Weterynaryjna
dc.relation.pages657-660
dc.rightsCC-BY-SA
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.enpalmitoylethanolamide
dc.subject.enpolyunsaturated fatty acids
dc.subject.endogs
dc.subject.enatopic dermatitis
dc.titleClinical evaluation of polyunsaturated fatty acids in combination with palmitoylethanolamide (PEA) in the treatment of signs of atopic dermatitis in dogs: Pilot study
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue10
oaire.citation.volume81