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Nine-Strain Bacterial Synbiotic Improves Crying and Lowers Fecal Calprotectin in Colicky Babies—An Open-Label Randomized Study

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dc.abstract.enThe aim of this study (ClinicalTrials.gov registration NCT04666324) was to determine the effects of a nine-strain synbiotic and simethicone on the duration of crying and the gut inflammation marker calprotectin in colicky babies aged 3–6 weeks, diagnosed using the Wessel criteria. The open-label study comprised a control group of non-colicky babies (n = 20) and two parallel treatment groups (each n = 50) to which colicky babies were randomly and equally assigned to receive the multi-strain synbiotic or simethicone orally for 28 days. Primary outcome measures were the change in daily crying duration and the level of fecal calprotectin on days 1 and 28 of the study. Administration of the synbiotic resulted in a rechange of crying duration of −7.18 min/day of treatment, while simethicone had a significantly smaller effect (−5.74 min/day). Fecal calprotectin levels in colicky babies were significantly elevated compared to those in non-colicky babies. Treatment with the nine-strain synbiotic resulted in a significant lowering of fecal calprotectin at the end of the study, while no such effect was found for simethicone. No adverse effects were reported. Study results confirm earlier findings of crying duration reductions in colicky babies by the synbiotic, an effect that might be linked to its anti-inflammatory properties.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorBernatek, Malgorzata
dc.contributor.authorPiątek, Jacek
dc.contributor.authorPszczoła, Marcin Jerzy
dc.contributor.authorKrauss, Hanna
dc.contributor.authorAntczak, Janina
dc.contributor.authorMaciukajć, Paweł
dc.contributor.authorSommermeyer, Henning
dc.date.access2026-01-09
dc.date.accessioned2026-01-09T09:50:38Z
dc.date.available2026-01-09T09:50:38Z
dc.date.copyright2022-02-12
dc.date.issued2022
dc.description.abstract<jats:p>The aim of this study (ClinicalTrials.gov registration NCT04666324) was to determine the effects of a nine-strain synbiotic and simethicone on the duration of crying and the gut inflammation marker calprotectin in colicky babies aged 3–6 weeks, diagnosed using the Wessel criteria. The open-label study comprised a control group of non-colicky babies (n = 20) and two parallel treatment groups (each n = 50) to which colicky babies were randomly and equally assigned to receive the multi-strain synbiotic or simethicone orally for 28 days. Primary outcome measures were the change in daily crying duration and the level of fecal calprotectin on days 1 and 28 of the study. Administration of the synbiotic resulted in a rechange of crying duration of −7.18 min/day of treatment, while simethicone had a significantly smaller effect (−5.74 min/day). Fecal calprotectin levels in colicky babies were significantly elevated compared to those in non-colicky babies. Treatment with the nine-strain synbiotic resulted in a significant lowering of fecal calprotectin at the end of the study, while no such effect was found for simethicone. No adverse effects were reported. Study results confirm earlier findings of crying duration reductions in colicky babies by the synbiotic, an effect that might be linked to its anti-inflammatory properties.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if4,5
dc.description.number2
dc.description.points40
dc.description.versionfinal_published
dc.description.volume10
dc.identifier.doi10.3390/microorganisms10020430
dc.identifier.issn2076-2607
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/6671
dc.identifier.weblinkhttps://www.mdpi.com/2076-2607/10/2/430
dc.languageen
dc.relation.ispartofMicroorganisms
dc.relation.pagesart. 430
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.encolic
dc.subject.encolicky babies
dc.subject.encrying
dc.subject.endysbiosis
dc.subject.enfecal calprotectin
dc.subject.engut inflammation
dc.subject.engut microbiota
dc.subject.eninfantile colic
dc.subject.ensimethicone
dc.subject.ensynbiotic
dc.titleNine-Strain Bacterial Synbiotic Improves Crying and Lowers Fecal Calprotectin in Colicky Babies—An Open-Label Randomized Study
dc.title.volumeSpecial Issue Probiotics and Synbiotics—Options to Manage Infections with Multi-Drug Resistant Bacteria?
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue2
oaire.citation.volume10