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Better safe than sorry - Whole-genome sequencing indicates that missense variants are significant in susceptibility to COVID-19

dc.abstract.enUndoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations. The majority of variants were synonymous (60.56% for severe, 58.46% for resistant phenotype) or located in introns (55.77% for severe, 59.83% for resistant phenotype). We identified the most significant SNPs for a severe outcome (in AJAP1 intron) and for COVID resistance (in FIG4 intron). We found no missense variants with a potential causal function on resistance to COVID-19; however, two missense variants were determined as significant a severe phenotype (in PM20D1 and LRP4 exons). None of the aforementioned SNPs and missense variants found in this study have been previously associated with COVID-19.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorSłomian, Dawid
dc.contributor.authorSzyda, Joanna
dc.contributor.authorDobosz, Paula
dc.contributor.authorStojak, Joanna
dc.contributor.authorMichalska-Foryszewska, Anna
dc.contributor.authorSypniewski, Mateusz
dc.contributor.authorLiu, Jakub
dc.contributor.authorKotlarz, Krzysztof
dc.contributor.authorSuchocki, Tomasz
dc.contributor.authorMroczek, Magdalena
dc.contributor.authorStępień, Maria
dc.contributor.authorSztromwasser, Paweł
dc.contributor.authorKról, Zbigniew J.
dc.date.access2025-08-22
dc.date.accessioned2025-10-28T11:43:10Z
dc.date.available2025-10-28T11:43:10Z
dc.date.copyright2023-01-20
dc.date.issued2023
dc.description.abstract<jats:p>Undoubtedly, genetic factors play an important role in susceptibility and resistance to COVID-19. In this study, we conducted the GWAS analysis. Out of 15,489,173 SNPs, we identified 18,191 significant SNPs for severe and 11,799 SNPs for resistant phenotype, showing that a great number of loci were significant in different COVID-19 representations. The majority of variants were synonymous (60.56% for severe, 58.46% for resistant phenotype) or located in introns (55.77% for severe, 59.83% for resistant phenotype). We identified the most significant SNPs for a severe outcome (in <jats:italic>AJAP1</jats:italic> intron) and for COVID resistance (in <jats:italic>FIG4</jats:italic> intron<jats:italic>)</jats:italic>. We found no missense variants with a potential causal function on resistance to COVID-19; however, two missense variants were determined as significant a severe phenotype (in <jats:italic>PM20D1</jats:italic> and <jats:italic>LRP4</jats:italic> exons). None of the aforementioned SNPs and missense variants found in this study have been previously associated with COVID-19.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.number1
dc.description.versionfinal_published
dc.description.volume18
dc.identifier.doi10.1371/journal.pone.0279356
dc.identifier.issn1932-6203
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/5535
dc.identifier.weblinkhttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0279356
dc.languageen
dc.relation.ispartofPLoS ONE
dc.relation.pagese0279356
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.titleBetter safe than sorry - Whole-genome sequencing indicates that missense variants are significant in susceptibility to COVID-19
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.issue1
oaire.citation.volume18