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A review: Pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals

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dc.abstract.enThe purpose of this review was to analyze the scientific literature on exocrine pancreatic insufficiency (EPI) in dogs and cats and our own research on porcine model to compare animal- and microbial-derived enzymes in the treatment of animals with this disease. Clinical signs of EPI occur when more than 85% of the pancreatic parenchyma is non-functional. EPI can be a consequence of various diseases. The insufficient activity or deficiency of pancreatic enzymes leads to impaired digestion and absorption, and consequently, to malnutrition. The primary treatment for enzyme insufficiency is pancreatic enzyme replacement therapy (PERT). PERT in animals with EPI is a lifetime therapy. Most commercially available products are of animal origin (processed pancreata obtained from a slaughter house) and contain lipases, alpha-amylase, and proteases. Enzymes of microbial and plant origin seem to be a promising alternative to animal-derived enzymes, but to date there are no registered preparations containing all enzymes simultaneously for use in clinical practice to treat EPI. Results from some previous studies have highlighted the “extra-digestive” functions of pancreatic enzymes, as well as the actions of pancreatic-like microbial enzymes. For example, trypsin activates protease-activated receptor and provokes maturation of enterocytes and enterostatin inhibits fat absorption. It has been postulated that intrapancreatic amylase is the main component of the acini-islet-acinar axis—the reflex which down regulates insulin release, while gut and blood amylase exhibit anti-incretin actions “per se.” Additionally, high but still physiological blood amylase activity coincide with physiological glucose homeostasis and a lack of obesity.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Nauk Przedklinicznych i Chorób Zakaźnych
dc.contributor.authorSzkopek, Dominika
dc.contributor.authorPierzynowski, Stefan G.
dc.contributor.authorPierzynowska, Kateryna
dc.contributor.authorZaworski, Kamil
dc.contributor.authorKondej, Agata
dc.contributor.authorWychowański, Piotr
dc.contributor.authorKonieczka, Paweł
dc.contributor.authorSeklecka, Blanka
dc.contributor.authorDonaldson, Janine
dc.contributor.authorJank, Michał
dc.contributor.authorWoliński, Jarosław
dc.date.access2024-08-12
dc.date.accessioned2024-07-03T07:40:14Z
dc.date.available2024-07-03T07:40:14Z
dc.date.copyright2024-05-09
dc.date.issued2024
dc.description.abstract<jats:title>Abstract</jats:title><jats:p>The purpose of this review was to analyze the scientific literature on exocrine pancreatic insufficiency (EPI) in dogs and cats and our own research on porcine model to compare animal‐ and microbial‐derived enzymes in the treatment of animals with this disease. Clinical signs of EPI occur when more than 85% of the pancreatic parenchyma is non‐functional. EPI can be a consequence of various diseases. The insufficient activity or deficiency of pancreatic enzymes leads to impaired digestion and absorption, and consequently, to malnutrition. The primary treatment for enzyme insufficiency is pancreatic enzyme replacement therapy (PERT). PERT in animals with EPI is a lifetime therapy. Most commercially available products are of animal origin (processed pancreata obtained from a slaughter house) and contain lipases, alpha‐amylase, and proteases. Enzymes of microbial and plant origin seem to be a promising alternative to animal‐derived enzymes, but to date there are no registered preparations containing all enzymes simultaneously for use in clinical practice to treat EPI. Results from some previous studies have highlighted the “extra‐digestive” functions of pancreatic enzymes, as well as the actions of pancreatic‐like microbial enzymes. For example, trypsin activates protease‐activated receptor and provokes maturation of enterocytes and enterostatin inhibits fat absorption. It has been postulated that intrapancreatic amylase is the main component of the acini‐islet‐acinar axis—the reflex which down regulates insulin release, while gut and blood amylase exhibit anti‐incretin actions “per se.” Additionally, high but still physiological blood amylase activity coincide with physiological glucose homeostasis and a lack of obesity.</jats:p>
dc.description.accesstimeat_publication
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,1
dc.description.number4
dc.description.points200
dc.description.versionfinal_published
dc.description.volume38
dc.identifier.doi10.1111/jvim.17096
dc.identifier.eissn0891-6640
dc.identifier.issn1939-1676
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1569
dc.languageen
dc.relation.ispartofJournal of Veterinary Internal Medicine
dc.relation.pages2026-2033
dc.rightsCC-BY
dc.sciencecloudsend
dc.share.typeOPEN_JOURNAL
dc.subject.enanimal-derived enzymes
dc.subject.enexocrine pancreatic insufficiency
dc.subject.enmicrobial-derived enzymes
dc.subject.enpancreatic replacement therapy
dc.subtypeReviewArticle
dc.titleA review: Pancreatic enzymes in the treatment of chronic pancreatic insufficiency in companion animals
dc.typeJournalArticle
dspace.entity.typePublication
project.funder.nameb.d.