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Epigenetic Control and Obesity

cris.virtual.author-orcid0000-0002-2045-0709
cris.virtualsource.author-orcid20ac3fe1-f398-4ef7-ab0b-a6a20460f69f
dc.abstract.enOverweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. These are among the greatest public health problems worldwide, as excess weight is a risk factor for numerous conditions, including diabetes, hypertension, stroke, and heart disease. In the general population overweight has a complex architecture, which means that it depends on genetic and environmental factors and on the interactions between them. Increasing evidence suggests that DNA methylation and other epigenetic mechanisms are involved in development and progression of obesity. Epigenome-wide association studies (EWAS) identified numerous loci associated with obesity or with the results on weight-loss interventions. However, heterogeneity in study design and analysis limits overlap in the results. Different types of non-coding RNAs have also been related to obesity as they are involved in stimulation or inhibition of adipogenesis and regulation of its metabolic and endocrine functions. The identification of reliable and reproducible epigenetic biomarkers for obesity and response to weight-loss therapies remains challenging.
dc.affiliationWydział Nauk o Żywności i Żywieniu
dc.affiliation.instituteKatedra Żywienia Człowieka i Dietetyki
dc.contributor.authorChmurzyńska, Agata
dc.contributor.editorVaschetto, Luis M.
dc.date.accessioned2024-08-14T09:34:59Z
dc.date.available2024-08-14T09:34:59Z
dc.date.issued2024
dc.description.bibliographybibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.points20
dc.description.reviewreview
dc.description.seriesEpigenetics and Human Health
dc.description.seriesnumber12
dc.identifier.doi10.1007/978-3-031-54215-2_10
dc.identifier.eisbn978-3-031-54215-2
dc.identifier.isbn978-3-031-54214-5
dc.identifier.serieseissn2191-2270
dc.identifier.seriesissn2191-2262
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/1649
dc.identifier.weblinkhttps://link.springer.com/book/10.1007/978-3-031-54215-2
dc.languageen
dc.pbn.affiliationfood and nutrition technology
dc.pubinfoCham
dc.publisher.ministerialSpringer
dc.relation.bookMolecular Mechanisms in Nutritional Epigenetics
dc.relation.pages217-235
dc.sciencecloudsend
dc.titleEpigenetic Control and Obesity
dc.typeMonographChapter
dspace.entity.typePublication
project.funder.nameb.d.