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Supporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin

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dc.abstract.enBackground: Infantile colic (IC) is a condition characterized by extensive crying which affects about 20% of all infants during their first months of life. Most pediatricians diagnose IC only based on their clinical experience. Aim: Investigating if a measurement of fecal calprotectin can support the diagnosis of IC. Methods: The crying behavior of newborns was assessed using the Wessel's criteria. Fecal calprotectin levels were measured in non-colicky and colicky babies using a standard test that can be used at the time and place of patient care (point of care (PoC) measurement). Results: Colicky babies were found to have significantly elevated fecal calprotectin levels. Calprotectin levels were not influenced by gender, type of feeding, gestation age or birth weight. However, significantly elevated fecal calprotectin levels were found in cesarean section born babies. Fecal calprotectin ≥100 μg/g correlated with a colicky status of an infant while those <100 μg/g indicated a non-colicky status the error margin was 11.2 and 13.2%, respectively. Combining data of fecal calprotectin with information about the type of delivery made it possible to determine the colicky status in vaginally-born infants with fecal calprotectin ≥100 μg/g with an accuracy of 97.8%. As elevated fecal calprotectin levels in cesarean-born infants can be caused by IC, but also by the disturbed gut microbiota commonly found in these babies, the accuracy of diagnosing the colicky status of a cesarean-born infant with calprotectin levels ≥100 μg/g was less accurate (accuracy rate of 76.5%). Conclusion: Data from the study suggest that measuring fecal calprotectin should be considered by pediatricians to support the diagnosis of IC.
dc.affiliationWydział Medycyny Weterynaryjnej i Nauk o Zwierzętach
dc.affiliation.instituteKatedra Genetyki i Podstaw Hodowli Zwierząt​​
dc.contributor.authorSommermeyer, Henning
dc.contributor.authorBernatek, Malgorzata
dc.contributor.authorPszczoła, Marcin Jerzy
dc.contributor.authorKrauss, Hanna
dc.contributor.authorPiatek, Jacek
dc.date.access2026-02-18
dc.date.accessioned2026-02-18T08:55:06Z
dc.date.available2026-02-18T08:55:06Z
dc.date.copyright2022-09-29
dc.date.issued2022
dc.description.abstract<jats:sec><jats:title>Background</jats:title><jats:p>Infantile colic (IC) is a condition characterized by extensive crying which affects about 20% of all infants during their first months of life. Most pediatricians diagnose IC only based on their clinical experience.</jats:p></jats:sec><jats:sec><jats:title>Aim</jats:title><jats:p>Investigating if a measurement of fecal calprotectin can support the diagnosis of IC.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>The crying behavior of newborns was assessed using the Wessel's criteria. Fecal calprotectin levels were measured in non-colicky and colicky babies using a standard test that can be used at the time and place of patient care (point of care (PoC) measurement).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Colicky babies were found to have significantly elevated fecal calprotectin levels. Calprotectin levels were not influenced by gender, type of feeding, gestation age or birth weight. However, significantly elevated fecal calprotectin levels were found in cesarean section born babies. Fecal calprotectin ≥100 μg/g correlated with a colicky status of an infant while those &amp;lt;100 μg/g indicated a non-colicky status the error margin was 11.2 and 13.2%, respectively. Combining data of fecal calprotectin with information about the type of delivery made it possible to determine the colicky status in vaginally-born infants with fecal calprotectin ≥100 μg/g with an accuracy of 97.8%. As elevated fecal calprotectin levels in cesarean-born infants can be caused by IC, but also by the disturbed gut microbiota commonly found in these babies, the accuracy of diagnosing the colicky status of a cesarean-born infant with calprotectin levels ≥100 μg/g was less accurate (accuracy rate of 76.5%).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Data from the study suggest that measuring fecal calprotectin should be considered by pediatricians to support the diagnosis of IC.</jats:p><jats:p>The study was registered at <jats:ext-link>ClinicalTrials.gov</jats:ext-link> under NCT04666324.</jats:p></jats:sec>
dc.description.accesstimeat_publication
dc.description.bibliographyil., bibliogr.
dc.description.financepublication_nocost
dc.description.financecost0,00
dc.description.if2,6
dc.description.points70
dc.description.versionfinal_published
dc.description.volume10
dc.identifier.doi10.3389/fped.2022.978545
dc.identifier.issn2296-2360
dc.identifier.urihttps://sciencerep.up.poznan.pl/handle/item/7372
dc.identifier.weblinkhttp://www.frontiersin.org/articles/10.3389/fped.2022.978545/full
dc.languageen
dc.relation.ispartofFrontiers in Pediatrics
dc.relation.pagesart. 978545
dc.rightsCC-BY
dc.sciencecloudnosend
dc.share.typeOPEN_JOURNAL
dc.subject.encolicky babies
dc.subject.engut microbiota
dc.subject.encesarean section
dc.subject.enfecal calprotectin (FC)
dc.subject.engut inflammation
dc.subject.eninfantile colic
dc.subject.enpoint of care diagnostic
dc.subject.envaginal birth
dc.titleSupporting the diagnosis of infantile colic by a point of care measurement of fecal calprotectin
dc.typeJournalArticle
dspace.entity.typePublication
oaire.citation.volume10